The Comparison of Sequestrectomy and Conventional Discectomy for the Treatment of a Lumbar Disc Herniation: A Systematic Review

Amir Azarhomayun, Saeedeh Shirdel, Alexander Vaccaro, Farhad Shokraneh, Soheil Saadat, Roger Chou, Vafa Rahimi-Movaghar

Research output: Contribution to journalComment/debatepeer-review


Study Design This is a systematic review. Objective This study aims to compare effects of sequestrectomy versus conventional microdiscectomy for lumbar disc herniation. Summary of Background data Open surgery for LDH can be performed by sequestrectomy or conventional discectomy. Generally, it has been assumed that the former is associated with higher risk of recurrence and less radicular pain and low back pain after surgery. Methods We searched MEDLINE and EMBASE from 1980 to November 2014. We selected randomized controlled trials (RCTs) and prospective studies that compared conventional discectomy versus sequestrectomy for adult patients with LDH and evaluated the following primary outcomes: radicular pain or LBP as measured by a visual analogue scale, neurological deficit of lower extremity. We also evaluated the following secondary outcomes: complications of surgery, reherniation rate, duration of hospital stay, postoperative analgesic use, and health-related quality of life measures. Two authors independently reviewed citations and articles for inclusion. We assessed the risk of bias as well as the level of evidence for each study, and we used standard methodological procedures recommended by the Cochrane Collaboration. Results We identified five studies (746 participants) that met our inclusion criteria comparing sequestrectomy versus microdiscectomy. Comparison revealed that with low-quality evidence, there is no significant difference for radicular pain, LBP, functional outcome, complications, and hospital stay for 2 years. In addition, with moderate-quality evidence, there is no significant difference for recurrence rate. Meanwhile, there is very low-quality evidence that analgesic consumption is lower in sequestrectomy than micro/discectomy. Conclusion Both interventions had similar effect on pain after surgery, recurrence rate, functional outcome, and complications; however, sequestrectomy may be superior in terms of postoperative analgesic consumption. discectomy sequestrectomy lumbar disc systematic review fragmentectomy.

Original languageEnglish (US)
JournalGlobal Spine Journal
Issue number1
StatePublished - May 2015

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine
  • Clinical Neurology


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