TY - JOUR
T1 - The continuum of growth hormone-IGF-I axis defects causing short stature
T2 - Diagnostic and therapeutic challenges
AU - Savage, Martin O.
AU - Burren, Christine P.
AU - Rosenfeld, Ron G.
PY - 2010/6
Y1 - 2010/6
N2 - The growth hormone (GH)-IGF-I axis is essential for normal foetal and childhood growth. Defects at different sites in the axis frequently result in short stature which may compromise adult height. We describe a continuum of clinically relevant abnormalities from GH deficiency through to GH resistance and discuss the implementation and interpretation of investigations. We consider appropriate therapy for patients with abnormal auxology and subnormal adult height prognosis, highlighting new data to clarify therapeutic choices leading to optimal clinical outcome.
AB - The growth hormone (GH)-IGF-I axis is essential for normal foetal and childhood growth. Defects at different sites in the axis frequently result in short stature which may compromise adult height. We describe a continuum of clinically relevant abnormalities from GH deficiency through to GH resistance and discuss the implementation and interpretation of investigations. We consider appropriate therapy for patients with abnormal auxology and subnormal adult height prognosis, highlighting new data to clarify therapeutic choices leading to optimal clinical outcome.
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UR - http://www.scopus.com/inward/citedby.url?scp=77952661532&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2265.2009.03775.x
DO - 10.1111/j.1365-2265.2009.03775.x
M3 - Review article
C2 - 20050859
AN - SCOPUS:77952661532
SN - 0300-0664
VL - 72
SP - 721
EP - 728
JO - Clinical Endocrinology
JF - Clinical Endocrinology
IS - 6
ER -