Recently Multiple Reports of a 'perforating condition' in chronic renal failure patients has rekindled interest in a heterogeneous group of diseases known best as the perforating disorders of dermatoses. Four entities in which epithelial perforation is a histologic hallmark are typically designated as 'specific' perforating conditions (elastosis perforans serpiginosa, reactive perforating collagenosis, perforating folliculitis, and Kyrle's disease, although more than a dozen other cutaneous diseases have now been reported to be occasionally characterized by epidermal perforation. The following discussion will consider variations in the dermatopathology of the four 'classic' perforating dermatoses as well as the history, concept, and mechanisms of transepithelial elimination (TE).
|Original language||English (US)|
|Number of pages||8|
|Journal||Seminars in Dermatology|
|State||Published - 1986|
ASJC Scopus subject areas