The development of Pneumocystis carinii pneumonia in germ-free rats requires immunosuppression and exposure to the Pneumocystis carinii organism

L. Wolff; S. Horch; D. Gemsa

doi:10.1016/0147-9571(93)90063-B

The development of Pneumocystis carinii pneumonia in germ-free rats requires immunosuppression and exposure to the Pneumocystis carinii organism

L. Wolff, S. Horch, D. Gemsa

Pediatrics

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Adult germ-free rats treated with dexamethasone and exposed to a non-sterile environment did not harbor or develop Pneumocystis carinii cysts or trophozoites after 10 weeks of immunosuppression. Only when they were exposed to infected, conventional rats and treated with dexamethasone for 8 weeks or longer, did adult germ-free rats develop P. carinii infection.

Original language	English (US)
Pages (from-to)	73-76
Number of pages	4
Journal	Comparative Immunology, Microbiology and Infectious Diseases
Volume	16
Issue number	1
DOIs	https://doi.org/10.1016/0147-9571(93)90063-B
State	Published - Jan 1993

Keywords

Pneumocystis carinii
immunosuppression
rats

ASJC Scopus subject areas

Microbiology
Immunology and Allergy
Immunology
General Veterinary
Infectious Diseases

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10.1016/0147-9571(93)90063-B

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abstract = "Adult germ-free rats treated with dexamethasone and exposed to a non-sterile environment did not harbor or develop Pneumocystis carinii cysts or trophozoites after 10 weeks of immunosuppression. Only when they were exposed to infected, conventional rats and treated with dexamethasone for 8 weeks or longer, did adult germ-free rats develop P. carinii infection.",

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AB - Adult germ-free rats treated with dexamethasone and exposed to a non-sterile environment did not harbor or develop Pneumocystis carinii cysts or trophozoites after 10 weeks of immunosuppression. Only when they were exposed to infected, conventional rats and treated with dexamethasone for 8 weeks or longer, did adult germ-free rats develop P. carinii infection.

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The development of Pneumocystis carinii pneumonia in germ-free rats requires immunosuppression and exposure to the Pneumocystis carinii organism

Abstract

Keywords

ASJC Scopus subject areas

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