The distressed daughter: Fatal forty DDI: Alprazolam, carbamazepine, CYP3A4

Jennifer Egan; Kirk Lalwani; Catherine Marcucci

doi:10.1007/978-1-4614-7495-1_82

The distressed daughter: Fatal forty DDI: Alprazolam, carbamazepine, CYP3A4

Jennifer Egan, Kirk Lalwani, Catherine Marcucci

Anesthesiology and Perioperative Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

This case discusses a pharmacokinetic interaction between carbamazepine and alprazolam leading to sedation. Alprazolam is a cytochrome P450 3A4 substrate. Carbamazapine is a 3A4 inducer. Discontinuation of carbamazepine leads to less metabolism of alprazolam and greater sedation.

Original language	English (US)
Title of host publication	A Case Approach to Perioperative Drug-Drug Interactions
Publisher	Springer New York
Pages	385-387
Number of pages	3
ISBN (Electronic)	9781461474951
ISBN (Print)	9781461474944
DOIs	https://doi.org/10.1007/978-1-4614-7495-1_82
State	Published - Sep 15 2015

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-4614-7495-1_82

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abstract = "This case discusses a pharmacokinetic interaction between carbamazepine and alprazolam leading to sedation. Alprazolam is a cytochrome P450 3A4 substrate. Carbamazapine is a 3A4 inducer. Discontinuation of carbamazepine leads to less metabolism of alprazolam and greater sedation.",

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The distressed daughter: Fatal forty DDI: Alprazolam, carbamazepine, CYP3A4

Abstract

ASJC Scopus subject areas

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