The durability of Laparoscopic Nissen fundoplication: 11-year outcomes

Craig B. Morgenthal, Matthew D. Shane, Alessandro Stival, Nana Gletsu, Graham Milam, Vickie Swafford, John G. Hunter, C. Daniel Smith

Research output: Contribution to journalArticlepeer-review

72 Scopus citations


Laparoscopic Nissen fundoplication (LNF) has become the most commonly performed antireflux procedure since its introduction in 1991. There are few studies with greater than 5-year outcomes. Herein we report a series of 312 consecutive patients who underwent primary LNF before 1996. Follow-up of more than 6 years was available in 166 patients, and the mean follow-up was 11 years (median 11.1 years, range 6.1-13.3 years). Prospective data collection included preoperative and current symptom scores (scale 0∈=∈none to 3∈=∈severe), as well as the level of patient satisfaction and use of antireflux medications. Total symptom score for each patient was summed from seven symptoms for a maximum value of 21. Heartburn and regurgitation were the most improved symptoms; however, all symptoms were significantly improved (P∈<∈0.01). The total symptom score at follow-up was 2.6 down from 7.5 at baseline, with a mean difference of -4.9 (range -12 to 3). The percentage of patients stating they would have the procedure again was 93.3%, and 70% were off daily antireflux medications. Outcomes at a mean of 11 years after LNF are excellent, and the majority of patients had their symptoms resolved or significantly improved and are satisfied with their results.

Original languageEnglish (US)
Pages (from-to)693-700
Number of pages8
JournalJournal of Gastrointestinal Surgery
Issue number6
StatePublished - Jun 2007


  • Antireflux surgery
  • GERD
  • Laparoscopic Nissen fundoplication
  • Long-term outcomes

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology


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