The effect of analgesic doses of morphine on regional cerebral glucose metabolism in pain-related structures

Robert M. Levy; Howard L. Fields; Michael P. Stryker; Mary M. Heinricher

doi:10.1016/0006-8993(86)91057-7

The effect of analgesic doses of morphine on regional cerebral glucose metabolism in pain-related structures

Robert M. Levy, Howard L. Fields, Michael P. Stryker, Mary M. Heinricher

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

The effect of morphine on regional cerebral glucose metabolism was measured in rats using high resolution [¹⁴C]2-deoxyglucose autoradiography with concurrent confirmation of morphine-induced analgesia measured by tail-flick latency to noxious heat. Within the limits of resolution of this technique, doses of morphine sufficient to inhibit the tail-flick reflex had no significant effect on glucose metabolism in structures implicated in the modulation of pain.

Original language	English (US)
Pages (from-to)	170-173
Number of pages	4
Journal	Brain research
Volume	368
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(86)91057-7
State	Published - Mar 12 1986
Externally published	Yes

Keywords

[C]2-deoxyglucose autoradiography
analgesia
morphine
pain
regional cerebral metabolism

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(86)91057-7

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title = "The effect of analgesic doses of morphine on regional cerebral glucose metabolism in pain-related structures",

abstract = "The effect of morphine on regional cerebral glucose metabolism was measured in rats using high resolution [14C]2-deoxyglucose autoradiography with concurrent confirmation of morphine-induced analgesia measured by tail-flick latency to noxious heat. Within the limits of resolution of this technique, doses of morphine sufficient to inhibit the tail-flick reflex had no significant effect on glucose metabolism in structures implicated in the modulation of pain.",

keywords = "[C]2-deoxyglucose autoradiography, analgesia, morphine, pain, regional cerebral metabolism",

author = "Levy, {Robert M.} and Fields, {Howard L.} and Stryker, {Michael P.} and Heinricher, {Mary M.}",

year = "1986",

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doi = "10.1016/0006-8993(86)91057-7",

language = "English (US)",

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AU - Levy, Robert M.

AU - Fields, Howard L.

AU - Stryker, Michael P.

AU - Heinricher, Mary M.

PY - 1986/3/12

Y1 - 1986/3/12

N2 - The effect of morphine on regional cerebral glucose metabolism was measured in rats using high resolution [14C]2-deoxyglucose autoradiography with concurrent confirmation of morphine-induced analgesia measured by tail-flick latency to noxious heat. Within the limits of resolution of this technique, doses of morphine sufficient to inhibit the tail-flick reflex had no significant effect on glucose metabolism in structures implicated in the modulation of pain.

AB - The effect of morphine on regional cerebral glucose metabolism was measured in rats using high resolution [14C]2-deoxyglucose autoradiography with concurrent confirmation of morphine-induced analgesia measured by tail-flick latency to noxious heat. Within the limits of resolution of this technique, doses of morphine sufficient to inhibit the tail-flick reflex had no significant effect on glucose metabolism in structures implicated in the modulation of pain.

KW - [C]2-deoxyglucose autoradiography

KW - analgesia

KW - morphine

KW - pain

KW - regional cerebral metabolism

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EP - 173

JO - Brain research

JF - Brain research

IS - 1

ER -

The effect of analgesic doses of morphine on regional cerebral glucose metabolism in pain-related structures

Abstract

Keywords

ASJC Scopus subject areas

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