TY - JOUR
T1 - The effect of low-level laser therapy (LLLT) applied prior to muscle injury
AU - Ribeiro, Beatriz Guimarães
AU - Alves, Agnelo Neves
AU - Santos, Lucas Andreo Dias Dos
AU - Fernandes, Kristianne Porta Santos
AU - Cantero, Tatiane Matarazzo
AU - Gomes, Mariana Teixeira
AU - França, Cristiane Miranda
AU - De Fátima Teixeira Da Silva, Daniela
AU - Bussadori, Sandra Kalil
AU - Mesquita-Ferrari, Raquel Agnelli
N1 - Publisher Copyright:
© 2015 Wiley Periodicals, Inc. © 2015 Wiley Periodicals, Inc.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - Aim To evaluate the effect of LLLT (780 nm; 10 J/cm2, 40 mW, 3.2 J) prior to injury on the morphological analysis, collagen deposition, and activity of matrix metalloproteinase-2 (MMP-2). Methods Wistar rats were divided into groups: control; sham; only LLLT; only muscle injury and LLLT + injury. The rats were euthanized at 1, 3, and 7 days following cryoinjury to muscle that was removed for analysis. Results LLLT applied prior to muscle injury led to a reduction in myonecrosis and inflammatory cells, an increase of blood vessels and immature muscle fibers. An increase in MMP-2 activity and a decrease in collagen deposition were also found, with a better collagen organization and distribution. Conclusion LLLT applied immediately prior to injury had positive effects during the muscle regeneration process. Therefore, this resource may have considerable therapeutic value, especially for athletes who practice sports in which there is a constant risk of muscle injury. Lasers Surg. Med. 47:571-578, 2015.
AB - Aim To evaluate the effect of LLLT (780 nm; 10 J/cm2, 40 mW, 3.2 J) prior to injury on the morphological analysis, collagen deposition, and activity of matrix metalloproteinase-2 (MMP-2). Methods Wistar rats were divided into groups: control; sham; only LLLT; only muscle injury and LLLT + injury. The rats were euthanized at 1, 3, and 7 days following cryoinjury to muscle that was removed for analysis. Results LLLT applied prior to muscle injury led to a reduction in myonecrosis and inflammatory cells, an increase of blood vessels and immature muscle fibers. An increase in MMP-2 activity and a decrease in collagen deposition were also found, with a better collagen organization and distribution. Conclusion LLLT applied immediately prior to injury had positive effects during the muscle regeneration process. Therefore, this resource may have considerable therapeutic value, especially for athletes who practice sports in which there is a constant risk of muscle injury. Lasers Surg. Med. 47:571-578, 2015.
KW - low-level laser therapy
KW - matrix metalloproteinase 2
KW - muscle
KW - regeneration collagen
KW - skeletal
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U2 - 10.1002/lsm.22381
DO - 10.1002/lsm.22381
M3 - Article
AN - SCOPUS:84940450321
SN - 0196-8092
VL - 47
SP - 571
EP - 578
JO - Lasers in Surgery and Medicine
JF - Lasers in Surgery and Medicine
IS - 7
ER -