The effect of photodynamic action on corneal cells in tissue culture

Moshe Lahav, Daniel M. Albert, Nancy L. Robinson, David K. Dueker

Research output: Contribution to journalArticlepeer-review


The effect of photodynamic inactivation on corneal epithelial, stromal and endothelial cells was investigated in tissue cultures. In contrast to reports regarding in vivo studies, the in vitro treatment caused significant degeneration and growth inhibition of stromal corneal cells and less marked changes of epithelial corneal cells in tissue cultures. Stationary endothelial cells appeared least effected. The neutral red was seen in the intracytoplasmic granules and in time localized mostly in the perinuclear area, and to a lesser extent within the nucleus. The in vitro study of actively growing corneal cells appears to be a sensitive indicator of cell damage following photoinactivation.

Original languageEnglish (US)
Pages (from-to)571-583
Number of pages13
JournalExperimental Eye Research
Issue number6
StatePublished - Jun 1975
Externally publishedYes

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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