The Effect of Prostaglandin E2 and Indomethacin on the Placental Vascular Response to Norepinephrine

Anne Berssenbrugge, Debra Anderson, Terrance Phernetton, John H.G. Rankin

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


The vascular response to norepinephrine is expressed in terms of a resistance ratio which is defined as the ratio of the vascular resistance seen 1.5 min after norepinephrine administration to that seen before norepinephrine administration. The injection of 1 μg/kg of norepinephrine to near-term sheep significantly increased the vascular resistance of the placenta to a ratio of 2.27 ± 0.52 (mean ± SEM; N = 7). Pretreatment with 20 jug of prostaglandin E2 per minute significantly decreased the placental response to norepinephrine to a resistance ratio of 1.47 ± 0.21 which was 65% of the untreated response (N = 7). Pretreatment with 10 mg/kg indomethacin significantly increased the placental response to norepinephrine from a resistance ratio of 2.25 ± 0.70 to 2.71 ± 0.84, which is 120% of the untreated value (N = 6). Prostaglandin E2 attenuated the placental vascular response to norepinephrine and indomethacin potentiated this response.

Original languageEnglish (US)
Pages (from-to)281-285
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number2
StatePublished - Nov 1978
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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