TY - JOUR
T1 - The effects of dietary cholesterol-lowering on psychological symptoms
T2 - A randomised controlled study
AU - Weidner, Gerdi
AU - Connor, Sonja L.
AU - Gerhard, Glenn T.
AU - Duell, P. Barton
AU - Connor, William E.
N1 - Funding Information:
We thank the participants, the dietitians (Lauren Hatcher, MS, RD; Reba Clow, BS, RD; Donna Flavell, BA, RD) and the nurses and support staff of the OHSU General Clinical Research Center, who were instrumental in the successful completion of the study. We also thank Heidi Mueller for analyzing the data, Loren Yglecias and Daniel Purnell for their helpful comments on this manuscript, and Dr. Nancy Mendell for her statistical advice. This publication was made possible with support from the Oregon Clinical and Translational Research Institute (OCTRI; UL1 RR024140) awarded by the National Center for Research Resources (NCRR), from the German Research Foundation (DFG; MA 155/75-1), and the Alexander von Humboldt Foundation.
PY - 2009/5
Y1 - 2009/5
N2 - The relationship of plasma cholesterol-reducing interventions to emotional states, such as depression and hostility, remains a topic of debate. The present study employed a randomised, controlled design, and was conducted at a clinical research center to test the effect of dietary cholesterol-lowering on psychological symptoms. Ten women and eight men were randomly assigned to one of two counterbalanced diet cycles (low-fat versus high-fat diet; isocaloric; 6 weeks each; separated by a washout period). Analyses for repeated measures revealed that the low-fat diet significantly reduced total, LDL and HDL cholesterol, when compared with baseline and the high-fat diet. As expected, weight remained unchanged. Ratings of depression, hostility and global severity of psychological symptoms as measured by the SCL-90-R also improved significantly on the low-fat, high-complex carbohydrate diet when compared with baseline. These results suggest that plasma cholesterol-lowering in the context of a low-fat, high-complex carbohydrate diet may have a beneficial effect on psychological symptoms.
AB - The relationship of plasma cholesterol-reducing interventions to emotional states, such as depression and hostility, remains a topic of debate. The present study employed a randomised, controlled design, and was conducted at a clinical research center to test the effect of dietary cholesterol-lowering on psychological symptoms. Ten women and eight men were randomly assigned to one of two counterbalanced diet cycles (low-fat versus high-fat diet; isocaloric; 6 weeks each; separated by a washout period). Analyses for repeated measures revealed that the low-fat diet significantly reduced total, LDL and HDL cholesterol, when compared with baseline and the high-fat diet. As expected, weight remained unchanged. Ratings of depression, hostility and global severity of psychological symptoms as measured by the SCL-90-R also improved significantly on the low-fat, high-complex carbohydrate diet when compared with baseline. These results suggest that plasma cholesterol-lowering in the context of a low-fat, high-complex carbohydrate diet may have a beneficial effect on psychological symptoms.
KW - Cholesterol-lowering
KW - Depression
KW - Diet
KW - Hostility
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U2 - 10.1080/13548500902730101
DO - 10.1080/13548500902730101
M3 - Article
C2 - 19444703
AN - SCOPUS:69149092397
SN - 1354-8506
VL - 14
SP - 255
EP - 261
JO - Psychology, Health and Medicine
JF - Psychology, Health and Medicine
IS - 3
ER -