The Ezh2 methyltransferase complex: Actin up in the cytosol

Jeffrey C. Nolz, Timothy S. Gomez, Daniel D. Billadeau

Research output: Contribution to journalShort surveypeer-review

22 Scopus citations


Ezh2, a polycomb group protein, is known to function in histone methylation, thereby regulating gene expression. However, in a recent study by Su et al., the Ezh2-containing complex has been given an additional role in cellular regulation. Cytosolic Ezh2 methyltransferase complexes were shown to associate with Vav1 and control receptor-induced actin polymerization and proliferation in a methylation-dependent manner. Overall, these findings implicate lysine methylation as a posttranslational modification crucial for receptor-mediated signal transduction events.

Original languageEnglish (US)
Pages (from-to)514-517
Number of pages4
JournalTrends in Cell Biology
Issue number10
StatePublished - Oct 2005
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology


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