The Fanconi Family Adds a Fraternal Twin

Markus Grompe; Henri van de Vrugt

doi:10.1016/j.devcel.2007.04.008

The Fanconi Family Adds a Fraternal Twin

Markus Grompe, Henri van de Vrugt

Research output: Contribution to journal › Short survey › peer-review

28 Scopus citations

Abstract

The Fanconi anemia (FA) pathway plays an important role in DNA repair. In a recent issue of Cell, Smogorzewska et al. (2007) now demonstrate that FANCD2 has a paralog, FANCI. FANCI and FANCD2 form the "ID" complex that loads onto chromatin after DNA damage. Like FANCD2, monoubiquitination of FANCI requires the FA core complex. Importantly, FANCI and FANCD2 monoubiquitination is codependent, suggesting a novel mechanism in ubiquitin conjugation.

Original language	English (US)
Pages (from-to)	661-662
Number of pages	2
Journal	Developmental Cell
Volume	12
Issue number	5
DOIs	https://doi.org/10.1016/j.devcel.2007.04.008
State	Published - May 8 2007

ASJC Scopus subject areas

Molecular Biology
General Biochemistry, Genetics and Molecular Biology
Developmental Biology
Cell Biology

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10.1016/j.devcel.2007.04.008

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abstract = "The Fanconi anemia (FA) pathway plays an important role in DNA repair. In a recent issue of Cell, Smogorzewska et al. (2007) now demonstrate that FANCD2 has a paralog, FANCI. FANCI and FANCD2 form the {"}ID{"} complex that loads onto chromatin after DNA damage. Like FANCD2, monoubiquitination of FANCI requires the FA core complex. Importantly, FANCI and FANCD2 monoubiquitination is codependent, suggesting a novel mechanism in ubiquitin conjugation.",

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AB - The Fanconi anemia (FA) pathway plays an important role in DNA repair. In a recent issue of Cell, Smogorzewska et al. (2007) now demonstrate that FANCD2 has a paralog, FANCI. FANCI and FANCD2 form the "ID" complex that loads onto chromatin after DNA damage. Like FANCD2, monoubiquitination of FANCI requires the FA core complex. Importantly, FANCI and FANCD2 monoubiquitination is codependent, suggesting a novel mechanism in ubiquitin conjugation.

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The Fanconi Family Adds a Fraternal Twin

Abstract

ASJC Scopus subject areas

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