The FDG lumped constant in normal human brain

Michael M. Graham; Mark Muzi; Alexander M. Spence; Finbarr O'Sullivan; Thomas K. Lewellen; Jeanne M. Link; Kenneth A. Krohn

The FDG lumped constant in normal human brain

Michael M. Graham, Mark Muzi, Alexander M. Spence, Finbarr O'Sullivan, Thomas K. Lewellen, Jeanne M. Link, Kenneth A. Krohn

Research output: Contribution to journal › Article › peer-review

96 Scopus citations

Abstract

The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MR_glc) from FDG metabolic rate (MR_FDG). Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MR_glc and MR_FDG independently using l-¹¹C-glucose and ¹⁸F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models. Results: The mean LC (±SD) for normal brain was found to be 0.89 ± 0.08. The value for cerebellum was slightly lower, 0.78 ± 0.11 (P = 0.006; 2-tailed paired t test). Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.

Original language	English (US)
Pages (from-to)	1157-1166
Number of pages	10
Journal	Journal of Nuclear Medicine
Volume	43
Issue number	9
State	Published - Sep 2002
Externally published	Yes

Keywords

C-glucose
FDG
Glucose metabolism
Lumped constant

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

Cite this

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title = "The FDG lumped constant in normal human brain",

abstract = "The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MRglc) from FDG metabolic rate (MRFDG). Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MRglc and MRFDG independently using l-11C-glucose and 18F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models. Results: The mean LC (±SD) for normal brain was found to be 0.89 ± 0.08. The value for cerebellum was slightly lower, 0.78 ± 0.11 (P = 0.006; 2-tailed paired t test). Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.",

keywords = "C-glucose, FDG, Glucose metabolism, Lumped constant",

author = "Graham, {Michael M.} and Mark Muzi and Spence, {Alexander M.} and Finbarr O'Sullivan and Lewellen, {Thomas K.} and Link, {Jeanne M.} and Krohn, {Kenneth A.}",

year = "2002",

month = sep,

language = "English (US)",

volume = "43",

pages = "1157--1166",

journal = "Journal of Nuclear Medicine",

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publisher = "Society of Nuclear Medicine Inc.",

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TY - JOUR

T1 - The FDG lumped constant in normal human brain

AU - Graham, Michael M.

AU - Muzi, Mark

AU - Spence, Alexander M.

AU - O'Sullivan, Finbarr

AU - Lewellen, Thomas K.

AU - Link, Jeanne M.

AU - Krohn, Kenneth A.

PY - 2002/9

Y1 - 2002/9

N2 - The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MRglc) from FDG metabolic rate (MRFDG). Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MRglc and MRFDG independently using l-11C-glucose and 18F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models. Results: The mean LC (±SD) for normal brain was found to be 0.89 ± 0.08. The value for cerebellum was slightly lower, 0.78 ± 0.11 (P = 0.006; 2-tailed paired t test). Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.

AB - The lumped constant (LC) is a correction factor used to infer glucose metabolic rate (MRglc) from FDG metabolic rate (MRFDG). Methods: LC was determined in normal brain in 10 subjects (4 male, 6 female) by measuring regional MRglc and MRFDG independently using l-11C-glucose and 18F-FDG with dynamic positron tomographic imaging, arterial blood sampling, and region-of-interest time-activity curve analysis with appropriate compartmental models. Results: The mean LC (±SD) for normal brain was found to be 0.89 ± 0.08. The value for cerebellum was slightly lower, 0.78 ± 0.11 (P = 0.006; 2-tailed paired t test). Conclusion: The LC values determined in this study are considerably higher than older values in the literature, probably because of methodologic differences, but agree with a recent study by Hasselbalch.

KW - C-glucose

KW - FDG

KW - Glucose metabolism

KW - Lumped constant

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JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 9

ER -

The FDG lumped constant in normal human brain

Abstract

Keywords

ASJC Scopus subject areas

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