TY - JOUR
T1 - The Gene Chase in Behavioral Science
AU - McClearn, Gerald E.
AU - Plomin, Robert
AU - Gora-Maslak, Grazyna
AU - Crabbe, John C.
N1 - Funding Information:
The original data collection was sponsored by the Veterans Administration and by grant DA 02799 from the National Institute on Drug Abuse. Development and application of the QTL analyses was supported by a gift from John Hanley and grant AA08125 from the-National Institute on Alcohol Abuse and Alcoholism.
PY - 1991/7
Y1 - 1991/7
N2 - The study of genetic influence on behavior has featured two general approaches. The first is to search for a single gene with influence sufficiently great as to be detectable against almost any genetic or environmental background. The second general approach is to apply the statistical models of quantitative genetics that partition variance of a continuously distributed phenotype into various fractions, attributable to the actions of many genes of individually small effect, and to the influence of environment. Recent developments in molecular genetics have provided tools for exploring a middle ground of genetic influence: genes whose effects are not overwhelming, but which account for appreciable proportions of the variance. These quantitative trait loci (QTL) offer attractive prospects of bridging the gap between molecular and quantitative genetic perspectives.
AB - The study of genetic influence on behavior has featured two general approaches. The first is to search for a single gene with influence sufficiently great as to be detectable against almost any genetic or environmental background. The second general approach is to apply the statistical models of quantitative genetics that partition variance of a continuously distributed phenotype into various fractions, attributable to the actions of many genes of individually small effect, and to the influence of environment. Recent developments in molecular genetics have provided tools for exploring a middle ground of genetic influence: genes whose effects are not overwhelming, but which account for appreciable proportions of the variance. These quantitative trait loci (QTL) offer attractive prospects of bridging the gap between molecular and quantitative genetic perspectives.
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U2 - 10.1111/j.1467-9280.1991.tb00139.x
DO - 10.1111/j.1467-9280.1991.tb00139.x
M3 - Article
AN - SCOPUS:84970107459
SN - 0956-7976
VL - 2
SP - 222
EP - 229
JO - Psychological Science
JF - Psychological Science
IS - 4
ER -