TY - JOUR
T1 - The great escape
T2 - Viral strategies to counter BST-2/ tetherin
AU - Douglas, Janet L.
AU - Gustin, Jean K.
AU - Viswanathan, Kasinath
AU - Mansouri, Mandana
AU - Moses, Ashlee V.
AU - Früh, Klaus
PY - 2010/5
Y1 - 2010/5
N2 - The interferon-induced BST-2 protein has the unique ability to restrict the egress of HIV-1, Kaposi's sarcoma-associated herpesvirus (KSHV), Ebola virus, and other enveloped viruses. The observation that virions remain attached to the surface of BST-2-expressing cells led to the renaming of BST-2 as "tetherin". However, viral proteins such as HIV-1 Vpu, simian immunodeficiency virus Nef, and KSHV K5 counteract BST-2, thereby allowing mature virions to readily escape from infected cells. Since the anti-viral function of BST-2 was discovered, there has been an explosion of research into several aspects of this intriguing interplay between host and virus. This review focuses on recent work addressing the molecular mechanisms involved in BST-2 restriction of viral egress and the species-specific countermeasures employed by various viruses.
AB - The interferon-induced BST-2 protein has the unique ability to restrict the egress of HIV-1, Kaposi's sarcoma-associated herpesvirus (KSHV), Ebola virus, and other enveloped viruses. The observation that virions remain attached to the surface of BST-2-expressing cells led to the renaming of BST-2 as "tetherin". However, viral proteins such as HIV-1 Vpu, simian immunodeficiency virus Nef, and KSHV K5 counteract BST-2, thereby allowing mature virions to readily escape from infected cells. Since the anti-viral function of BST-2 was discovered, there has been an explosion of research into several aspects of this intriguing interplay between host and virus. This review focuses on recent work addressing the molecular mechanisms involved in BST-2 restriction of viral egress and the species-specific countermeasures employed by various viruses.
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U2 - 10.1371/journal.ppat.1000913
DO - 10.1371/journal.ppat.1000913
M3 - Review article
C2 - 20485522
AN - SCOPUS:77954037568
SN - 1553-7366
VL - 6
SP - 1
EP - 12
JO - PLoS pathogens
JF - PLoS pathogens
IS - 5
ER -