The impact of receptor desensitization on fast synaptic transmission

Mathew V. Jones; Gary L. Westbrook

doi:10.1016/S0166-2236(96)80037-3

The impact of receptor desensitization on fast synaptic transmission

Mathew V. Jones, Gary L. Westbrook

Vollum Institute

Research output: Contribution to journal › Article › peer-review

407 Scopus citations

Abstract

The role of desensitization of ligand-gated channels at fast chemical synapses has been difficult to establish. Desensitization has been studied traditionally with prolonged agonist exposure, whereas the duration of free neurotransmitter in the synaptic cleft is relatively brief. Studies of acetylcholine-, glutamate- and GABA-gated channels using rapid agonist application now provide a means to assess the effects of desensitization in shaping synaptic responses and in influencing neuronal excitability. These data reveal several strikingly different patterns by which the receptor-specific kinetics of desensitization can determine the size, time course and frequency of transmitted signals. Desensitization is thus a surprisingly versatile mechanism for shaping synaptic transmissions.

Original language	English (US)
Pages (from-to)	96-101
Number of pages	6
Journal	Trends in Neurosciences
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/S0166-2236(96)80037-3
State	Published - Mar 1996

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0166-2236(96)80037-3

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title = "The impact of receptor desensitization on fast synaptic transmission",

abstract = "The role of desensitization of ligand-gated channels at fast chemical synapses has been difficult to establish. Desensitization has been studied traditionally with prolonged agonist exposure, whereas the duration of free neurotransmitter in the synaptic cleft is relatively brief. Studies of acetylcholine-, glutamate- and GABA-gated channels using rapid agonist application now provide a means to assess the effects of desensitization in shaping synaptic responses and in influencing neuronal excitability. These data reveal several strikingly different patterns by which the receptor-specific kinetics of desensitization can determine the size, time course and frequency of transmitted signals. Desensitization is thus a surprisingly versatile mechanism for shaping synaptic transmissions.",

author = "Jones, {Mathew V.} and Westbrook, {Gary L.}",

note = "Funding Information: discussions and criticism, and \ohn Dani, Robin Lester and James Dilger for comments on desensitization of nirotinic ACh receptors. This work wus supported in part by F32 NSO9716 (ML{\textquoteright}\) and NSZ6494 and MH46613 (GL W).",

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The impact of receptor desensitization on fast synaptic transmission

Abstract

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