The inflammatory tumor microenvironment and its impact on cancer development.

Karin E. de Visser, Lisa M. Coussens

Research output: Contribution to journalReview articlepeer-review

197 Scopus citations


The role of the immune system during cancer development is complex involving extensive reciprocal interactions between genetically altered cells, adaptive and innate immune cells, their soluble mediators and structural components present in the neoplastic microenvironment. Each stage of cancer development is regulated uniquely by the immune system; whereas full activation of adaptive immune cells at the tumor stage may result in eradication of malignant cells, chronic activation of innate immune cells at sites of premalignant growth may actually enhance tumor development. In addition, the balance between desirable antitumor immune responses and undesirable pro-tumor chronic inflammatory responses largely depends on the context in which a malignancy is developing. The following chapter focuses on the inflammatory components and processes engaged during cancer development and the impact of the inflammatory microenvironment.

Original languageEnglish (US)
Pages (from-to)118-137
Number of pages20
JournalContributions to microbiology
StatePublished - 2006
Externally publishedYes

ASJC Scopus subject areas

  • General Immunology and Microbiology
  • Microbiology (medical)
  • Infectious Diseases


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