The 'ins' and 'outs' of podosomes and invadopodia: Characteristics, formation and function

Danielle A. Murphy, Sara A. Courtneidge

Research output: Contribution to journalReview articlepeer-review

812 Scopus citations


Podosomes and invadopodia are actin-based dynamic protrusions of the plasma membrane of metazoan cells that represent sites of attachment to - and degradation of - the extracellular matrix. The key proteins in these structures include the actin regulators cortactin and neural Wiskott-Aldrich syndrome protein (N-WASP), the adaptor proteins Tyr kinase substrate with four SH3 domains (TKS4) and Tyr kinase substrate with five SH3 domains (TKS5), and the metalloprotease membrane type 1 matrix metalloprotease (MT1MMP; also known as MMP14). Many cell types can produce these structures, including invasive cancer cells, vascular smooth muscle and endothelial cells, and immune cells such as macrophages and dendritic cells. Recently, progress has been made in our understanding of the regulatory and functional aspects of podosome and invadopodium biology and their role in human disease.

Original languageEnglish (US)
Pages (from-to)413-426
Number of pages14
JournalNature Reviews Molecular Cell Biology
Issue number7
StatePublished - Jun 2011
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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