The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine

Dane Dickson; Jennifer Johnson; Raymond Bergan; Rebecca Owens; Vivek Subbiah; Razelle Kurzrock

doi:10.1016/j.cell.2019.12.009

The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine

Dane Dickson, Jennifer Johnson, Raymond Bergan, Rebecca Owens, Vivek Subbiah, Razelle Kurzrock

Knight Cancer Institute

Research output: Contribution to journal › Comment/debate › peer-review

38 Scopus citations

Abstract

This commentary introduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the power of molecularly based master interventional protocols with the breadth of real-world data. The MOT provides a clinical venue to allow molecular medicine to rapidly advance, answers questions that traditional interventional trials generally do not address, and seamlessly integrates with interventional trials in both diagnostic and therapeutic arenas. The result is a more comprehensive data collection ecosystem in precision medicine.

Original language	English (US)
Pages (from-to)	9-14
Number of pages	6
Journal	Cell
Volume	180
Issue number	1
DOIs	https://doi.org/10.1016/j.cell.2019.12.009
State	Published - Jan 9 2020

Keywords

ROOT
evidence
innovation
innovation
master
protocol
quality
real-world data
trial

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.cell.2019.12.009

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title = "The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine",

abstract = "This commentary introduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the power of molecularly based master interventional protocols with the breadth of real-world data. The MOT provides a clinical venue to allow molecular medicine to rapidly advance, answers questions that traditional interventional trials generally do not address, and seamlessly integrates with interventional trials in both diagnostic and therapeutic arenas. The result is a more comprehensive data collection ecosystem in precision medicine.",

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AU - Bergan, Raymond

AU - Owens, Rebecca

AU - Subbiah, Vivek

AU - Kurzrock, Razelle

PY - 2020/1/9

Y1 - 2020/1/9

N2 - This commentary introduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the power of molecularly based master interventional protocols with the breadth of real-world data. The MOT provides a clinical venue to allow molecular medicine to rapidly advance, answers questions that traditional interventional trials generally do not address, and seamlessly integrates with interventional trials in both diagnostic and therapeutic arenas. The result is a more comprehensive data collection ecosystem in precision medicine.

AB - This commentary introduces a new clinical trial construct, the Master Observational Trial (MOT), which hybridizes the power of molecularly based master interventional protocols with the breadth of real-world data. The MOT provides a clinical venue to allow molecular medicine to rapidly advance, answers questions that traditional interventional trials generally do not address, and seamlessly integrates with interventional trials in both diagnostic and therapeutic arenas. The result is a more comprehensive data collection ecosystem in precision medicine.

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KW - quality

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The Master Observational Trial: A New Class of Master Protocol to Advance Precision Medicine

Abstract

Keywords

ASJC Scopus subject areas

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