The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

Deanne M. Taylor; Bruce J. Aronow; Kai Tan; Kathrin Bernt; Nathan Salomonis; Casey S. Greene; Alina Frolova; Sarah E. Henrickson; Andrew Wells; Liming Pei; Jyoti K. Jaiswal; Jeffrey Whitsett; Kathryn E. Hamilton; Sonya A. MacParland; Judith Kelsen; Robert O. Heuckeroth; S. Steven Potter; Laura A. Vella; Natalie A. Terry; Louis R. Ghanem; Benjamin C. Kennedy; Ingo Helbig; Kathleen E. Sullivan; Leslie Castelo-Soccio; Arnold Kreigstein; Florian Herse; Martijn C. Nawijn; Gerard H. Koppelman; Melissa Haendel; Nomi L. Harris; Jo Lynne Rokita; Yuanchao Zhang; Aviv Regev; Orit Rozenblatt-Rosen; Jennifer E. Rood; Timothy L. Tickle; Roser Vento-Tormo; Saif Alimohamed; Monkol Lek; Jessica C. Mar; Kathleen M. Loomes; David M. Barrett; Prech Uapinyoying; Alan H. Beggs; Pankaj B. Agrawal; Yi Wen Chen; Amanda B. Muir; Lana X. Garmire; Scott B. Snapper; Javad Nazarian; Steven H. Seeholzer; Hossein Fazelinia; Larry N. Singh; Robert B. Faryabi; Pichai Raman; Noor Dawany; Hongbo Michael Xie; Batsal Devkota; Sharon J. Diskin; Stewart A. Anderson; Eric F. Rappaport; William Peranteau; Kathryn A. Wikenheiser-Brokamp; Sarah Teichmann; Douglas Wallace; Tao Peng; Yang yang Ding; Man S. Kim; Yi Xing; Sek Won Kong; Carsten G. Bönnemann; Kenneth D. Mandl; Peter S. White

doi:10.1016/j.devcel.2019.03.001

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

Deanne M. Taylor, Bruce J. Aronow, Kai Tan, Kathrin Bernt, Nathan Salomonis, Casey S. Greene, Alina Frolova, Sarah E. Henrickson, Andrew Wells, Liming Pei, Jyoti K. Jaiswal, Jeffrey Whitsett, Kathryn E. Hamilton, Sonya A. MacParland, Judith Kelsen, Robert O. Heuckeroth, S. Steven Potter, Laura A. Vella, Natalie A. Terry, Louis R. GhanemBenjamin C. Kennedy, Ingo Helbig, Kathleen E. Sullivan, Leslie Castelo-Soccio, Arnold Kreigstein, Florian Herse, Martijn C. Nawijn, Gerard H. Koppelman, Melissa Haendel, Nomi L. Harris, Jo Lynne Rokita, Yuanchao Zhang, Aviv Regev, Orit Rozenblatt-Rosen, Jennifer E. Rood, Timothy L. Tickle, Roser Vento-Tormo, Saif Alimohamed, Monkol Lek, Jessica C. Mar, Kathleen M. Loomes, David M. Barrett, Prech Uapinyoying, Alan H. Beggs, Pankaj B. Agrawal, Yi Wen Chen, Amanda B. Muir, Lana X. Garmire, Scott B. Snapper, Javad Nazarian, Steven H. Seeholzer, Hossein Fazelinia, Larry N. Singh, Robert B. Faryabi, Pichai Raman, Noor Dawany, Hongbo Michael Xie, Batsal Devkota, Sharon J. Diskin, Stewart A. Anderson, Eric F. Rappaport, William Peranteau, Kathryn A. Wikenheiser-Brokamp, Sarah Teichmann, Douglas Wallace, Tao Peng, Yang yang Ding, Man S. Kim, Yi Xing, Sek Won Kong, Carsten G. Bönnemann, Kenneth D. Mandl, Peter S. White

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Abstract

Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. We discuss the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.

Original language	English (US)
Pages (from-to)	10-29
Number of pages	20
Journal	Developmental Cell
Volume	49
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2019.03.001
State	Published - Apr 8 2019

ASJC Scopus subject areas

Molecular Biology
Biochemistry, Genetics and Molecular Biology(all)
Developmental Biology
Cell Biology

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10.1016/j.devcel.2019.03.001

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Taylor, D. M., Aronow, B. J., Tan, K., Bernt, K., Salomonis, N., Greene, C. S., Frolova, A., Henrickson, S. E., Wells, A., Pei, L., Jaiswal, J. K., Whitsett, J., Hamilton, K. E., MacParland, S. A., Kelsen, J., Heuckeroth, R. O., Potter, S. S., Vella, L. A., Terry, N. A., ... White, P. S. (2019). The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution. Developmental Cell, 49(1), 10-29. https://doi.org/10.1016/j.devcel.2019.03.001

Taylor, DM, Aronow, BJ, Tan, K, Bernt, K, Salomonis, N, Greene, CS, Frolova, A, Henrickson, SE, Wells, A, Pei, L, Jaiswal, JK, Whitsett, J, Hamilton, KE, MacParland, SA, Kelsen, J, Heuckeroth, RO, Potter, SS, Vella, LA, Terry, NA, Ghanem, LR, Kennedy, BC, Helbig, I, Sullivan, KE, Castelo-Soccio, L, Kreigstein, A, Herse, F, Nawijn, MC, Koppelman, GH, Haendel, M, Harris, NL, Rokita, JL, Zhang, Y, Regev, A, Rozenblatt-Rosen, O, Rood, JE, Tickle, TL, Vento-Tormo, R, Alimohamed, S, Lek, M, Mar, JC, Loomes, KM, Barrett, DM, Uapinyoying, P, Beggs, AH, Agrawal, PB, Chen, YW, Muir, AB, Garmire, LX, Snapper, SB, Nazarian, J, Seeholzer, SH, Fazelinia, H, Singh, LN, Faryabi, RB, Raman, P, Dawany, N, Xie, HM, Devkota, B, Diskin, SJ, Anderson, SA, Rappaport, EF, Peranteau, W, Wikenheiser-Brokamp, KA, Teichmann, S, Wallace, D, Peng, T, Ding, YY, Kim, MS, Xing, Y, Kong, SW, Bönnemann, CG, Mandl, KD & White, PS 2019, 'The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution', Developmental Cell, vol. 49, no. 1, pp. 10-29. https://doi.org/10.1016/j.devcel.2019.03.001

@article{0edbdb8edcbb4da88063b21ad49ce570,

title = "The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution",

abstract = "Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. We discuss the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.",

author = "Taylor, {Deanne M.} and Aronow, {Bruce J.} and Kai Tan and Kathrin Bernt and Nathan Salomonis and Greene, {Casey S.} and Alina Frolova and Henrickson, {Sarah E.} and Andrew Wells and Liming Pei and Jaiswal, {Jyoti K.} and Jeffrey Whitsett and Hamilton, {Kathryn E.} and MacParland, {Sonya A.} and Judith Kelsen and Heuckeroth, {Robert O.} and Potter, {S. Steven} and Vella, {Laura A.} and Terry, {Natalie A.} and Ghanem, {Louis R.} and Kennedy, {Benjamin C.} and Ingo Helbig and Sullivan, {Kathleen E.} and Leslie Castelo-Soccio and Arnold Kreigstein and Florian Herse and Nawijn, {Martijn C.} and Koppelman, {Gerard H.} and Melissa Haendel and Harris, {Nomi L.} and Rokita, {Jo Lynne} and Yuanchao Zhang and Aviv Regev and Orit Rozenblatt-Rosen and Rood, {Jennifer E.} and Tickle, {Timothy L.} and Roser Vento-Tormo and Saif Alimohamed and Monkol Lek and Mar, {Jessica C.} and Loomes, {Kathleen M.} and Barrett, {David M.} and Prech Uapinyoying and Beggs, {Alan H.} and Agrawal, {Pankaj B.} and Chen, {Yi Wen} and Muir, {Amanda B.} and Garmire, {Lana X.} and Snapper, {Scott B.} and Javad Nazarian and Seeholzer, {Steven H.} and Hossein Fazelinia and Singh, {Larry N.} and Faryabi, {Robert B.} and Pichai Raman and Noor Dawany and Xie, {Hongbo Michael} and Batsal Devkota and Diskin, {Sharon J.} and Anderson, {Stewart A.} and Rappaport, {Eric F.} and William Peranteau and Wikenheiser-Brokamp, {Kathryn A.} and Sarah Teichmann and Douglas Wallace and Tao Peng and Ding, {Yang yang} and Kim, {Man S.} and Yi Xing and Kong, {Sek Won} and B{\"o}nnemann, {Carsten G.} and Mandl, {Kenneth D.} and White, {Peter S.}",

note = "Funding Information: D.M.T.: NIH 5P01HD070454-09, 5U2CHL138346-02; B.J.A.: NIH P30 DK078392, U01 HL122642, HL122638, U19 MH104172, MH194173; K.T.: NIH U2C CA233285 and U01 CA226197; C.S.G.: Alex's Lemonade Stand Foundation, grant 2018-182718 from the Chan-Zuckerberg Initiative DAF, Gordon and Betty Moore Foundation grant GBMF 4552, and NIH R01 HG010067; K.E.H.: NIH K01DK100485 and NIH R03DK114463; S.E.H.: NIH 5K12HD043245 and K08 AI135091; L.P.: DoD PRMRP award W81XWH-16-1-0400 and NIH DK111495; A.H.B.: NIH R01AR044345 and MDA602235 from the Muscular Dystrophy Association (USA); N.S. B.J.A.: the Cincinnati Children's Research Foundation; L.X.G.: NIH K01ES025434, P20 COBRE GM103457, R01 LM012373, R01 HD084633; D.M.T. Y.Z. M.S.K. B.D.: the Department of Biomedical and Health Informatics and the CHOP Research Institute; S.W.K.: NIH R01MH107205; A.R. is an Investigator of the Howard Hughes Medical Institute. A.R. is an SAB member of ThermoFisher Scientific and Syros Pharmaceuticals and a founder and equity holder of Celsius Therapeutics. S.W.K. receives sponsored research support from Pfizer Inc. Funding Information: D.M.T.: NIH 5P01HD070454-09 , 5U2CHL138346-02 ; B.J.A.: NIH P30 DK078392 , U01 HL122642 , HL122638 , U19 MH104172 , MH194173 ; K.T.: NIH U2C CA233285 and U01 CA226197 ; C.S.G.: Alex's Lemonade Stand Foundation , grant 2018-182718 from the Chan-Zuckerberg Initiative DAF, Gordon and Betty Moore Foundation grant GBMF 4552 , and NIH R01 HG010067 ; K.E.H.: NIH K01DK100485 and NIH R03DK114463 ; S.E.H.: NIH 5K12HD043245 and K08 AI135091 ; L.P.: DoD PRMRP award W81XWH-16-1-0400 and NIH DK111495 ; A.H.B.: NIH R01AR044345 and MDA602235 from the Muscular Dystrophy Association (USA); N.S., B.J.A.: the Cincinnati Children's Research Foundation; L.X.G.: NIH K01ES025434 , P20 COBRE GM103457 , R01 LM012373 , R01 HD084633 ; D.M.T., Y.Z., M.S.K., B.D.: the Department of Biomedical and Health Informatics and the CHOP Research Institute; S.W.K.: NIH R01MH107205 ; A.R. is an Investigator of the Howard Hughes Medical Institute. Funding Information: A.R. is an SAB member of ThermoFisher Scientific and Syros Pharmaceuticals and a founder and equity holder of Celsius Therapeutics. S.W.K. receives sponsored research support from Pfizer Inc. Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = apr,

day = "8",

doi = "10.1016/j.devcel.2019.03.001",

language = "English (US)",

volume = "49",

pages = "10--29",

journal = "Developmental Cell",

issn = "1534-5807",

publisher = "Cell Press",

number = "1",

}

TY - JOUR

T1 - The Pediatric Cell Atlas

T2 - Defining the Growth Phase of Human Development at Single-Cell Resolution

AU - Taylor, Deanne M.

AU - Aronow, Bruce J.

AU - Tan, Kai

AU - Bernt, Kathrin

AU - Salomonis, Nathan

AU - Greene, Casey S.

AU - Frolova, Alina

AU - Henrickson, Sarah E.

AU - Wells, Andrew

AU - Pei, Liming

AU - Jaiswal, Jyoti K.

AU - Whitsett, Jeffrey

AU - Hamilton, Kathryn E.

AU - MacParland, Sonya A.

AU - Kelsen, Judith

AU - Heuckeroth, Robert O.

AU - Potter, S. Steven

AU - Vella, Laura A.

AU - Terry, Natalie A.

AU - Ghanem, Louis R.

AU - Kennedy, Benjamin C.

AU - Helbig, Ingo

AU - Sullivan, Kathleen E.

AU - Castelo-Soccio, Leslie

AU - Kreigstein, Arnold

AU - Herse, Florian

AU - Nawijn, Martijn C.

AU - Koppelman, Gerard H.

AU - Haendel, Melissa

AU - Harris, Nomi L.

AU - Rokita, Jo Lynne

AU - Zhang, Yuanchao

AU - Regev, Aviv

AU - Rozenblatt-Rosen, Orit

AU - Rood, Jennifer E.

AU - Tickle, Timothy L.

AU - Vento-Tormo, Roser

AU - Alimohamed, Saif

AU - Lek, Monkol

AU - Mar, Jessica C.

AU - Loomes, Kathleen M.

AU - Barrett, David M.

AU - Uapinyoying, Prech

AU - Beggs, Alan H.

AU - Agrawal, Pankaj B.

AU - Chen, Yi Wen

AU - Muir, Amanda B.

AU - Garmire, Lana X.

AU - Snapper, Scott B.

AU - Nazarian, Javad

AU - Seeholzer, Steven H.

AU - Fazelinia, Hossein

AU - Singh, Larry N.

AU - Faryabi, Robert B.

AU - Raman, Pichai

AU - Dawany, Noor

AU - Xie, Hongbo Michael

AU - Devkota, Batsal

AU - Diskin, Sharon J.

AU - Anderson, Stewart A.

AU - Rappaport, Eric F.

AU - Peranteau, William

AU - Wikenheiser-Brokamp, Kathryn A.

AU - Teichmann, Sarah

AU - Wallace, Douglas

AU - Peng, Tao

AU - Ding, Yang yang

AU - Kim, Man S.

AU - Xing, Yi

AU - Kong, Sek Won

AU - Bönnemann, Carsten G.

AU - Mandl, Kenneth D.

AU - White, Peter S.

N1 - Funding Information: D.M.T.: NIH 5P01HD070454-09, 5U2CHL138346-02; B.J.A.: NIH P30 DK078392, U01 HL122642, HL122638, U19 MH104172, MH194173; K.T.: NIH U2C CA233285 and U01 CA226197; C.S.G.: Alex's Lemonade Stand Foundation, grant 2018-182718 from the Chan-Zuckerberg Initiative DAF, Gordon and Betty Moore Foundation grant GBMF 4552, and NIH R01 HG010067; K.E.H.: NIH K01DK100485 and NIH R03DK114463; S.E.H.: NIH 5K12HD043245 and K08 AI135091; L.P.: DoD PRMRP award W81XWH-16-1-0400 and NIH DK111495; A.H.B.: NIH R01AR044345 and MDA602235 from the Muscular Dystrophy Association (USA); N.S. B.J.A.: the Cincinnati Children's Research Foundation; L.X.G.: NIH K01ES025434, P20 COBRE GM103457, R01 LM012373, R01 HD084633; D.M.T. Y.Z. M.S.K. B.D.: the Department of Biomedical and Health Informatics and the CHOP Research Institute; S.W.K.: NIH R01MH107205; A.R. is an Investigator of the Howard Hughes Medical Institute. A.R. is an SAB member of ThermoFisher Scientific and Syros Pharmaceuticals and a founder and equity holder of Celsius Therapeutics. S.W.K. receives sponsored research support from Pfizer Inc. Funding Information: D.M.T.: NIH 5P01HD070454-09 , 5U2CHL138346-02 ; B.J.A.: NIH P30 DK078392 , U01 HL122642 , HL122638 , U19 MH104172 , MH194173 ; K.T.: NIH U2C CA233285 and U01 CA226197 ; C.S.G.: Alex's Lemonade Stand Foundation , grant 2018-182718 from the Chan-Zuckerberg Initiative DAF, Gordon and Betty Moore Foundation grant GBMF 4552 , and NIH R01 HG010067 ; K.E.H.: NIH K01DK100485 and NIH R03DK114463 ; S.E.H.: NIH 5K12HD043245 and K08 AI135091 ; L.P.: DoD PRMRP award W81XWH-16-1-0400 and NIH DK111495 ; A.H.B.: NIH R01AR044345 and MDA602235 from the Muscular Dystrophy Association (USA); N.S., B.J.A.: the Cincinnati Children's Research Foundation; L.X.G.: NIH K01ES025434 , P20 COBRE GM103457 , R01 LM012373 , R01 HD084633 ; D.M.T., Y.Z., M.S.K., B.D.: the Department of Biomedical and Health Informatics and the CHOP Research Institute; S.W.K.: NIH R01MH107205 ; A.R. is an Investigator of the Howard Hughes Medical Institute. Funding Information: A.R. is an SAB member of ThermoFisher Scientific and Syros Pharmaceuticals and a founder and equity holder of Celsius Therapeutics. S.W.K. receives sponsored research support from Pfizer Inc. Publisher Copyright: © 2019 The Authors

PY - 2019/4/8

Y1 - 2019/4/8

N2 - Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. We discuss the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.

AB - Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. We discuss the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan.

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UR - http://www.scopus.com/inward/citedby.url?scp=85063638054&partnerID=8YFLogxK

U2 - 10.1016/j.devcel.2019.03.001

DO - 10.1016/j.devcel.2019.03.001

M3 - Review article

C2 - 30930166

AN - SCOPUS:85063638054

SN - 1534-5807

VL - 49

SP - 10

EP - 29

JO - Developmental Cell

JF - Developmental Cell

IS - 1

ER -

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

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