The Presto 1000: A novel automated transcranial Doppler ultrasound system

Seunggu J. Han, William Caleb Rutledge, Dario J. Englot, Ethan A. Winkler, Janet L. Browne, Lauren Pflugrath, David Cronsier, Adib A. Abla, Michel Kliot, Michael T. Lawton

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


We examined the reliability and ease of use of a novel automated transcranial Doppler (TCD) system in comparison to a conventional TCD system. TCD ultrasound allows non-invasive monitoring of cerebral blood flow, and can predict arterial vasospasm after a subarachnoid hemorrhage (SAH). The Presto 1000 TCD system (PhysioSonics, Bellevue, WA, USA) is designed for monitoring flow through the M1 segment of the middle cerebral artery (MCA) via temporal windows. The Presto 1000 system was tested across multiple preclinical and clinical settings in parallel with a control predicate TCD system. In a phantom flow generating device, both the Presto 1000 and Spencer system (Spencer Technologies, Redmond, WA, USA) were able to detect velocities with high accuracy. In nine volunteer patients, the Presto system was able to locate the MCA in 14 out of 18 temporal windows, in an average of 12.5 s. In the SAH cohort of five patients with a total of 25 paired measurements, the mean absolute difference in flow velocities of the M1 segment, as measured by the two systems, was 17.5 cm/s. These data suggest that the Presto system offers an automated TCD that can reliably localize and detect flow of the MCA, with relative ease of use. The system carries the additional benefit of requiring minimal training for the operator, and can be used by many providers across multiple bedside settings. The mean velocities that were generated warrant further validation across an extended group of patients, and the predictive value for vasospasm should be checked against the current standard of angiography.

Original languageEnglish (US)
Pages (from-to)1771-1775
Number of pages5
JournalJournal of Clinical Neuroscience
Issue number11
StatePublished - Nov 2015


  • Automated
  • Middle cerebral artery
  • Subarachnoid hemorrhage
  • Transcranial Doppler
  • Vasospasm
  • Velocity

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)


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