The Public Access Defibrillation (PAD) Trial: Study design and rationale

Joseph P. Ornato, Mary Ann McBurnie, Graham Nichol, Marcel Salive, Myron Weisfeldt, Barbara Riegel, James Christenson, Thomas Therndrup, Mohamud Daya, N. Clay Mann, Brent Shaum, Kimberlee Brown, Kammy Jacobsen, Robert Zalenski, Scott Compton, Robert Dunne, Robert Swor, Robert Welch, Lynn Marie Mango, Kristen BilickiMary D. Gunnels, Jerris R. Hedges, Jonathan Jui, Terri Schmidt, Lynn Wittwer, Heather Brooks, Christopher Burke, Denise Griffiths, Lance B. Becker, Anne Barry, Ellen Demertsidies, Michael R. Sayre, Jim Christenson, Sarah Pennington, Allan Holmes, Heather Payne, Roland Webb, Nadia Douglas, Patricia Lawson, Mark C. Henry, Scott Johnson, Edward R. Stapleton, Jonathan VanZile, Michael Ottaway, Robert E. O'Connor, Patricia McGraw, Missy Bollinger, Ross E. Megargel, Stephen Ehrlich, Bruce Haynes, Linda Asbury, Shannon Stephens, Sarah D. McNutt, William J. Groh, Deb Cordes, Susan J. Bondurant, Max Harry Weil, Michael Osur, Brian MacGavin, Britta Myrin, Ruchir Sehra, Vijayaraghavan Krishnaswami, Thomas Mattioni, Vince N. Mosesso, Brian K. Slater, Venard J. Campbell, David Hostler, Richard A. Craven, Lois A. Bosken, Patricia Burke, Judith Paulsen, Gary Newton, Lynne D. Richardson, Frederick Ehlert, Christopher Freyberg, Neal Richmond, Christopher Shields, Ilene Wilets, Jennifer Holohan, Andy R. Anton, Constance D. Jones, Stephen Yahn, Dennis Rabel, David B. Reed, Lawrence H. Brown, Lisa M. Evans, Brian D. Mahoney, Rachel Knudson-Ballard, Mary Ann Peberdy, Elizabeth Ferry Godburn, Daniel Harker, J. Jerry Overton, Richard O. Cummins, Alidene Doherty, Tom P. Aufderheide, Ronald G. Pirrallo, Lisa Parmenter, Laura Grabowski, Eleanor B. Schron

Research output: Contribution to journalReview articlepeer-review

90 Scopus citations


The PAD Trial is a prospective, multicenter, randomized clinical study testing whether volunteer, non-medical responders can improve survival from out-of-hospital cardiac arrest (OOH-CA) by using automated external defibrillators (AEDs). These lay volunteers, who have no traditional responsibility to respond to a medical emergency as part of their primary job description, will form part of a comprehensive, integrated community approach to the treatment of OOH-CA. The study is being conducted at 24 field centers in the United States and Canada. Approximately 1000 community units (e.g. apartment or office buildings, gated communities, sports facilities, senior centers, shopping malls, etc.) were randomized to treatment by trained laypersons who will provide either cardiopulmonary resuscitation (CPR) alone or CPR plus use of an AED, while awaiting arrival of the community's emergency medical services responders. The primary endpoint is the number of OOH-CA victims who survive to hospital discharge. Secondary endpoints include neurological status, health-related quality of life (HRQL), cost, and cost-effectiveness. Data collection will last approximately 15 months and is expected to be completed in September 2003.

Original languageEnglish (US)
Pages (from-to)135-147
Number of pages13
Issue number2
StatePublished - Feb 1 2003


  • Automated external defibrillator (AED)
  • Cardiopulmonary resuscitation (CPR)
  • Defibrillation
  • Emergency medical services (EMS)
  • Out-of-hospital cardiac arrest (OOH-CA)
  • Ventricular fibrillation (VF)

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency
  • Cardiology and Cardiovascular Medicine


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