@article{157121b25329406bbf1551d801425dd8,
title = "The QT interval and risk of incident atrial fibrillation",
abstract = "Background Abnormal atrial repolarization is important in the development of atrial fibrillation (AF), but no direct measurement is available in clinical medicine. Objective To determine whether the QT interval, a marker of ventricular repolarization, could be used to predict incident AF. Methods We examined a prolonged QT interval corrected by using the Framingham formula (QTFram) as a predictor of incident AF in the Atherosclerosis Risk in Communities (ARIC) study. The Cardiovascular Health Study (CHS) and Health, Aging, and Body Composition (ABC) study were used for validation. Secondary predictors included QT duration as a continuous variable, a short QT interval, and QT intervals corrected by using other formulas. Results Among 14,538 ARIC study participants, a prolonged QTFram predicted a roughly 2-fold increased risk of AF (hazard ratio [HR] 2.05; 95% confidence interval [CI] 1.42-2.96; P <.001). No substantive attenuation was observed after adjustment for age, race, sex, study center, body mass index, hypertension, diabetes, coronary disease, and heart failure. The findings were validated in Cardiovascular Health Study and Health, Aging, and Body Composition study and were similar across various QT correction methods. Also in the ARIC study, each 10-ms increase in QTFram was associated with an increased unadjusted (HR 1.14; 95% CI 1.10-1.17; P <.001) and adjusted (HR 1.11; 95% CI 1.07-1.14; P <.001) risk of AF. Findings regarding a short QT interval were inconsistent across cohorts. Conclusions A prolonged QT interval is associated with an increased risk of incident AF.",
keywords = "Atrial fibrillation, ECG, Electrocardiogram, Epidemiology, QTinterval, Risk",
author = "Mandyam, {Mala C.} and Soliman, {Elsayed Z.} and Alvaro Alonso and Dewland, {Thomas A.} and Heckbert, {Susan R.} and Eric Vittinghoff and Cummings, {Steven R.} and Ellinor, {Patrick T.} and Chaitman, {Bernard R.} and Karen Stocke and Applegate, {William B.} and Arking, {Dan E.} and Javed Butler and Loehr, {Laura R.} and Magnani, {Jared W.} and Murphy, {Rachel A.} and Suzanne Satterfield and Newman, {Anne B.} and Marcus, {Gregory M.}",
note = "Funding Information: This research was supported by the following: For the University of California San Francisco{\textquoteright}s Clinical & Translational Science Institute (UCSF CTSI): the National Center for Research Resources, the National Center for Advancing Translational Sciences, and the Office of the Director, National Institutes of Health (NIH), through UCSF-CTSI grant number TL1 RR024129 ; for the Atherosclerosis Risk in Communities (ARIC) study: a collaborative support from National Heart, Lung, and Blood Institute (NHLBI) contracts HHSN268201100005C, HHSN268201100006C, HHSN268201100007C, HHSN268201100008C, HHSN268201100009C, HHSN268201100010C, HHSN268201100011C, and HHSN268201100012C; for the Cardiovascular Health Study (CHS): a support from NHLBI contracts HHSN268201200036C, N01HC85239, N01 HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, and N01HC85086 and grants HL080295 and HL068986, with additional contribution from the National Institute of Neurological Disorders and Stroke. Additional support was provided by AG023629 from the National Institute on Aging (NIA). A full list of principal CHS investigators and institutions can be found at http://www.chs-nhlbi.org/PI.htm ; for the Health, Aging, and Body Composition (Health ABC) study: a support from NIA contracts N01-AG-6-2101, N01-AG-6-2103, and N01-AG-6-2106 and grant R01-AG028050, as well as the National Institute of Nursing Research grant R01-NR012459. This research was supported in part by the Intramural Research Program of the NIH, NIA. The contents of this publication are solely the responsibility of the authors and do not necessarily represent the official views of any of the supporting agencies or sources. ",
year = "2013",
month = oct,
doi = "10.1016/j.hrthm.2013.07.023",
language = "English (US)",
volume = "10",
pages = "1562--1568",
journal = "Heart Rhythm",
issn = "1547-5271",
publisher = "Elsevier",
number = "10",
}