The Reactome pathway knowledgebase

David Croft; Antonio Fabregat Mundo; Robin Haw; Marija Milacic; Joel Weiser; Guanming Wu; Michael Caudy; Phani Garapati; Marc Gillespie; Maulik R. Kamdar; Bijay Jassal; Steven Jupe; Lisa Matthews; Bruce May; Stanislav Palatnik; Karen Rothfels; Veronica Shamovsky; Heeyeon Song; Mark Williams; Ewan Birney; Henning Hermjakob; Lincoln Stein; Peter D'Eustachio

doi:10.1093/nar/gkt1102

The Reactome pathway knowledgebase

David Croft, Antonio Fabregat Mundo, Robin Haw, Marija Milacic, Joel Weiser, Guanming Wu, Michael Caudy, Phani Garapati, Marc Gillespie, Maulik R. Kamdar, Bijay Jassal, Steven Jupe, Lisa Matthews, Bruce May, Stanislav Palatnik, Karen Rothfels, Veronica Shamovsky, Heeyeon Song, Mark Williams, Ewan BirneyHenning Hermjakob, Lincoln Stein, Peter D'Eustachio

Research output: Contribution to journal › Article › peer-review

1187 Scopus citations

Abstract

Reactome (http://www.reactome.org) is a manually curated open-source open-data resource of human pathways and reactions. The current version 46 describes 7088 human proteins (34% of the predicted human proteome), participating in 6744 reactions based on data extracted from 15 107 research publications with PubMed links. The Reactome Web site and analysis tool set have been completely redesigned to increase speed, flexibility and user friendliness. The data model has been extended to support annotation of disease processes due to infectious agents and to mutation.

Original language	English (US)
Pages (from-to)	D472-D477
Journal	Nucleic acids research
Volume	42
Issue number	D1
DOIs	https://doi.org/10.1093/nar/gkt1102
State	Published - Jan 1 2014
Externally published	Yes

ASJC Scopus subject areas

Genetics

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Croft, D., Mundo, A. F., Haw, R., Milacic, M., Weiser, J., Wu, G., Caudy, M., Garapati, P., Gillespie, M., Kamdar, M. R., Jassal, B., Jupe, S., Matthews, L., May, B., Palatnik, S., Rothfels, K., Shamovsky, V., Song, H., Williams, M., ... D'Eustachio, P. (2014). The Reactome pathway knowledgebase. Nucleic acids research, 42(D1), D472-D477. https://doi.org/10.1093/nar/gkt1102

Croft, D, Mundo, AF, Haw, R, Milacic, M, Weiser, J, Wu, G, Caudy, M, Garapati, P, Gillespie, M, Kamdar, MR, Jassal, B, Jupe, S, Matthews, L, May, B, Palatnik, S, Rothfels, K, Shamovsky, V, Song, H, Williams, M, Birney, E, Hermjakob, H, Stein, L & D'Eustachio, P 2014, 'The Reactome pathway knowledgebase', Nucleic acids research, vol. 42, no. D1, pp. D472-D477. https://doi.org/10.1093/nar/gkt1102

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note = "Funding Information: National Human Genome Research Institute at the National Institutes of Health [U41 HG003751]; Ontario Research (GL2) fund; European Bioinformatics Institute; European Commission (PSIMEx); Google Summer of Code Program (2011–2013). Funding for open access charge: National Institutes of Health [U41 HG003751].",

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AU - Milacic, Marija

AU - Weiser, Joel

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AU - Caudy, Michael

AU - Garapati, Phani

AU - Gillespie, Marc

AU - Kamdar, Maulik R.

AU - Jassal, Bijay

AU - Jupe, Steven

AU - Matthews, Lisa

AU - May, Bruce

AU - Palatnik, Stanislav

AU - Rothfels, Karen

AU - Shamovsky, Veronica

AU - Song, Heeyeon

AU - Williams, Mark

AU - Birney, Ewan

AU - Hermjakob, Henning

AU - Stein, Lincoln

AU - D'Eustachio, Peter

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The Reactome pathway knowledgebase

Abstract

ASJC Scopus subject areas

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