The Reactome pathway knowledgebase

David Croft, Antonio Fabregat Mundo, Robin Haw, Marija Milacic, Joel Weiser, Guanming Wu, Michael Caudy, Phani Garapati, Marc Gillespie, Maulik R. Kamdar, Bijay Jassal, Steven Jupe, Lisa Matthews, Bruce May, Stanislav Palatnik, Karen Rothfels, Veronica Shamovsky, Heeyeon Song, Mark Williams, Ewan BirneyHenning Hermjakob, Lincoln Stein, Peter D'Eustachio

Research output: Contribution to journalArticlepeer-review

1187 Scopus citations


Reactome ( is a manually curated open-source open-data resource of human pathways and reactions. The current version 46 describes 7088 human proteins (34% of the predicted human proteome), participating in 6744 reactions based on data extracted from 15 107 research publications with PubMed links. The Reactome Web site and analysis tool set have been completely redesigned to increase speed, flexibility and user friendliness. The data model has been extended to support annotation of disease processes due to infectious agents and to mutation.

Original languageEnglish (US)
Pages (from-to)D472-D477
JournalNucleic acids research
Issue numberD1
StatePublished - Jan 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Genetics


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