The Reactome Pathway Knowledgebase 2024

Marija Milacic; Deidre Beavers; Patrick Conley; Chuqiao Gong; Marc Gillespie; Johannes Griss; Robin Haw; Bijay Jassal; Lisa Matthews; Bruce May; Robert Petryszak; Eliot Ragueneau; Karen Rothfels; Cristoffer Sevilla; Veronica Shamovsky; Ralf Stephan; Krishna Tiwari; Thawfeek Varusai; Joel Weiser; Adam Wright; Guanming Wu; Lincoln Stein; Henning Hermjakob; Peter D'Eustachio

doi:10.1093/nar/gkad1025

The Reactome Pathway Knowledgebase 2024

Marija Milacic, Deidre Beavers, Patrick Conley, Chuqiao Gong, Marc Gillespie, Johannes Griss, Robin Haw, Bijay Jassal, Lisa Matthews, Bruce May, Robert Petryszak, Eliot Ragueneau, Karen Rothfels, Cristoffer Sevilla, Veronica Shamovsky, Ralf Stephan, Krishna Tiwari, Thawfeek Varusai, Joel Weiser, Adam WrightGuanming Wu, Lincoln Stein, Henning Hermjakob, Peter D'Eustachio

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

The R eactome Kno wledgebase ( https://reactome.org ),ãn Elixirãnd GCBR core biological data resource, provides manually curated molecular details ofã broad range of normalãnd disease-related biological processes. Processesãreãnnotatedãsãn ordered network of molecular transformations inã single consistent data model. Reactome thus functions bothãsã digitalãrchive of manually curated human biological processesãndãsã tool f or disco v ering functional relationships in data suchãs gene expression profiles or somatic mutation catalogs from tumor cells. Here w e re vie w progress to wãrdsãnnotation of the entire human proteome, tãrgetedãnnotãtion of disease-causing genetic variants of proteinsãnd of small-molecule drugs inã pathwã y conte xt,ãnd to wãrds supporting explicitãnnotation of cell-ãnd tissue-specific pathwã y s. Finally, we briefly discuss issues involved in making Reactome more fully interoperable with other related resources suchãs the Gene Ontologyãnd maintaining the resulting community resource network.

Original language	English (US)
Pages (from-to)	D672-D678
Journal	Nucleic acids research
Volume	52
Issue number	D1
DOIs	https://doi.org/10.1093/nar/gkad1025
State	Published - Jan 5 2024

ASJC Scopus subject areas

Genetics

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10.1093/nar/gkad1025

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Milacic, M., Beavers, D., Conley, P., Gong, C., Gillespie, M., Griss, J., Haw, R., Jassal, B., Matthews, L., May, B., Petryszak, R., Ragueneau, E., Rothfels, K., Sevilla, C., Shamovsky, V., Stephan, R., Tiwari, K., Varusai, T., Weiser, J., ... D'Eustachio, P. (2024). The Reactome Pathway Knowledgebase 2024. Nucleic acids research, 52(D1), D672-D678. https://doi.org/10.1093/nar/gkad1025

Milacic, M, Beavers, D, Conley, P, Gong, C, Gillespie, M, Griss, J, Haw, R, Jassal, B, Matthews, L, May, B, Petryszak, R, Ragueneau, E, Rothfels, K, Sevilla, C, Shamovsky, V, Stephan, R, Tiwari, K, Varusai, T, Weiser, J, Wright, A, Wu, G, Stein, L, Hermjakob, H & D'Eustachio, P 2024, 'The Reactome Pathway Knowledgebase 2024', Nucleic acids research, vol. 52, no. D1, pp. D672-D678. https://doi.org/10.1093/nar/gkad1025

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author = "Marija Milacic and Deidre Beavers and Patrick Conley and Chuqiao Gong and Marc Gillespie and Johannes Griss and Robin Haw and Bijay Jassal and Lisa Matthews and Bruce May and Robert Petryszak and Eliot Ragueneau and Karen Rothfels and Cristoffer Sevilla and Veronica Shamovsky and Ralf Stephan and Krishna Tiwari and Thawfeek Varusai and Joel Weiser and Adam Wright and Guanming Wu and Lincoln Stein and Henning Hermjakob and Peter D'Eustachio",

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AU - Griss, Johannes

AU - Haw, Robin

AU - Jassal, Bijay

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AU - Petryszak, Robert

AU - Ragueneau, Eliot

AU - Rothfels, Karen

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AU - Shamovsky, Veronica

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AU - Tiwari, Krishna

AU - Varusai, Thawfeek

AU - Weiser, Joel

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AU - Wu, Guanming

AU - Stein, Lincoln

AU - Hermjakob, Henning

AU - D'Eustachio, Peter

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The Reactome Pathway Knowledgebase 2024

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