TY - JOUR
T1 - The role of endogenous opiates in athletic amenorrhea
AU - Samuels, M. H.
AU - Sanborn, C. F.
AU - Hofeldt, F.
AU - Robbins, R.
N1 - Funding Information:
Received March 28, 1990; revised and accepted October 25, 1990. * Supported in part by Adult General Clinical Research Center grant MOl RR00051 University of Colorado Health Science Center, Denver, Colorado, and National Institutes of Health grant DK 36843-03 Bethesda, Maryland. t Reprint requests and present address: Mary H. Samuels, M.D., University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7877. :j: Present address: Department of Kinesiology, Texas Woman's University, Denton, Texas. §Division of Endocrinology. II Present address: Section of Neuroendocrinology, Yale University School of Medicine, New Haven, Connecticut.
PY - 1991
Y1 - 1991
N2 - We hypothesized that menstrual disturbances in female athletes arise from opioid-induced abnormalities in gonadotropin and/or prolactin (PRL) secretion. To investigate this hypothesis, we measured luteinizing hormone, follicle-stimulating hormone, and PRL levels in eumenorrheic and amenorrheic athletes during thyrotropin-releasing hormone and gonadotropin-releasing hormone tests at baseline, after naloxone infusions, after exercise to exhaustion, and after similar exercise during naloxone infusions. Contrary to our hypothesis, amenorrheic runners did not have significant alterations in basal, postexercise, or stimulated hormone levels compared with eumenorrheic runners. In addition, opioid blockade by naloxone did not enhance gonadotropin release by amenorrheic athletes.
AB - We hypothesized that menstrual disturbances in female athletes arise from opioid-induced abnormalities in gonadotropin and/or prolactin (PRL) secretion. To investigate this hypothesis, we measured luteinizing hormone, follicle-stimulating hormone, and PRL levels in eumenorrheic and amenorrheic athletes during thyrotropin-releasing hormone and gonadotropin-releasing hormone tests at baseline, after naloxone infusions, after exercise to exhaustion, and after similar exercise during naloxone infusions. Contrary to our hypothesis, amenorrheic runners did not have significant alterations in basal, postexercise, or stimulated hormone levels compared with eumenorrheic runners. In addition, opioid blockade by naloxone did not enhance gonadotropin release by amenorrheic athletes.
UR - http://www.scopus.com/inward/record.url?scp=0025968633&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025968633&partnerID=8YFLogxK
U2 - 10.1016/s0015-0282(16)54176-4
DO - 10.1016/s0015-0282(16)54176-4
M3 - Article
C2 - 1900478
AN - SCOPUS:0025968633
SN - 0015-0282
VL - 55
SP - 507
EP - 512
JO - Fertility and sterility
JF - Fertility and sterility
IS - 3
ER -