The role of iron repletion in adult iron deficiency anemia and other diseases

Benjamin Elstrott, Lubna Khan, Sven Olson, Vikram Raghunathan, Thomas DeLoughery, Joseph J. Shatzel

Research output: Contribution to journalReview articlepeer-review

40 Scopus citations


Iron deficiency anemia (IDA) is the most prevalent and treatable form of anemia worldwide. The clinical management of patients with IDA requires a comprehensive understanding of the many etiologies that can lead to iron deficiency including pregnancy, blood loss, renal disease, heavy menstrual bleeding, inflammatory bowel disease, bariatric surgery, or extremely rare genetic disorders. The treatment landscape for many causes of IDA is currently shifting toward more abundant use of intravenous (IV) iron due to its effectiveness and improved formulations that decrease the likelihood of adverse effects. IV iron has found applications beyond treatment of IDA, and there is accruing data about its efficacy in patients with heart failure, restless leg syndrome, fatigue, and prevention of acute mountain sickness. This review provides a framework to diagnose, manage, and treat patients presenting with IDA and discusses other conditions that benefit from iron supplementation.

Original languageEnglish (US)
Pages (from-to)153-161
Number of pages9
JournalEuropean Journal of Haematology
Issue number3
StatePublished - Mar 1 2020


  • anemia
  • hematopathology
  • iron deficiency
  • iron repletion

ASJC Scopus subject areas

  • Hematology


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