The role of protein adduction in toxic neuropathies of exogenous and endogenous origin

Peter S. Spencer; Xiao Chen

doi:10.3390/toxics9050098

The role of protein adduction in toxic neuropathies of exogenous and endogenous origin

Peter S. Spencer, Xiao Chen

Neurology

Research output: Contribution to journal › Review article › peer-review

7 Scopus citations

Abstract

The peripheral (axonal) neuropathy associated with repeated exposure to aliphatic and aromatic solvents that form protein-reactive γ-diketones shares some clinical and neuropathological features with certain metabolic neuropathies, including type-II diabetic neuropathy and uremic neuropathy, and with the largely sub-clinical nerve damage associated with old age. These conditions may be linked by metabolites that adduct and cross-link neuroproteins required for the maintenance of axonal transport and nerve fiber integrity in the peripheral and central nervous system.

Original language	English (US)
Article number	98
Journal	Toxics
Volume	9
Issue number	5
DOIs	https://doi.org/10.3390/toxics9050098
State	Published - May 2021

Keywords

Advanced glycation end product
Aging
Amino acid pyrrolation
Central-peripheral distal axonopathy
Diabetic neuropathy
Protein cross-linking
Uremic neuropathy
γ-diketone

ASJC Scopus subject areas

Toxicology
Chemical Health and Safety
Health, Toxicology and Mutagenesis

Access to Document

10.3390/toxics9050098

Cite this

@article{ef7b692c1b0d4eadb8e0e6f441ed84f2,

title = "The role of protein adduction in toxic neuropathies of exogenous and endogenous origin",

abstract = "The peripheral (axonal) neuropathy associated with repeated exposure to aliphatic and aromatic solvents that form protein-reactive γ-diketones shares some clinical and neuropathological features with certain metabolic neuropathies, including type-II diabetic neuropathy and uremic neuropathy, and with the largely sub-clinical nerve damage associated with old age. These conditions may be linked by metabolites that adduct and cross-link neuroproteins required for the maintenance of axonal transport and nerve fiber integrity in the peripheral and central nervous system.",

keywords = "Advanced glycation end product, Aging, Amino acid pyrrolation, Central-peripheral distal axonopathy, Diabetic neuropathy, Protein cross-linking, Uremic neuropathy, γ-diketone",

author = "Spencer, {Peter S.} and Xiao Chen",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

month = may,

doi = "10.3390/toxics9050098",

language = "English (US)",

volume = "9",

journal = "Toxics",

issn = "2305-6304",

publisher = "MDPI AG",

number = "5",

}

TY - JOUR

T1 - The role of protein adduction in toxic neuropathies of exogenous and endogenous origin

AU - Spencer, Peter S.

AU - Chen, Xiao

PY - 2021/5

Y1 - 2021/5

N2 - The peripheral (axonal) neuropathy associated with repeated exposure to aliphatic and aromatic solvents that form protein-reactive γ-diketones shares some clinical and neuropathological features with certain metabolic neuropathies, including type-II diabetic neuropathy and uremic neuropathy, and with the largely sub-clinical nerve damage associated with old age. These conditions may be linked by metabolites that adduct and cross-link neuroproteins required for the maintenance of axonal transport and nerve fiber integrity in the peripheral and central nervous system.

AB - The peripheral (axonal) neuropathy associated with repeated exposure to aliphatic and aromatic solvents that form protein-reactive γ-diketones shares some clinical and neuropathological features with certain metabolic neuropathies, including type-II diabetic neuropathy and uremic neuropathy, and with the largely sub-clinical nerve damage associated with old age. These conditions may be linked by metabolites that adduct and cross-link neuroproteins required for the maintenance of axonal transport and nerve fiber integrity in the peripheral and central nervous system.

KW - Advanced glycation end product

KW - Aging

KW - Amino acid pyrrolation

KW - Central-peripheral distal axonopathy

KW - Diabetic neuropathy

KW - Protein cross-linking

KW - Uremic neuropathy

KW - γ-diketone

UR - http://www.scopus.com/inward/record.url?scp=85105882296&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85105882296&partnerID=8YFLogxK

U2 - 10.3390/toxics9050098

DO - 10.3390/toxics9050098

M3 - Review article

AN - SCOPUS:85105882296

SN - 2305-6304

VL - 9

JO - Toxics

JF - Toxics

IS - 5

M1 - 98

ER -

The role of protein adduction in toxic neuropathies of exogenous and endogenous origin

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this