The Substantia Nigra Pars Reticulata in Sedative-Hypnotic Withdrawal

Lauren C. Kruse, Kari J. Buck

Research output: Chapter in Book/Report/Conference proceedingChapter


Sedative-hypnotic drugs including alcohol, benzodiazepines, and barbiturates, are widely used and abused for their euphoric and sedative properties. Sedative-hypnotic abuse and addiction is a complex, heterogeneous disorder, with biological (genetic) factors strongly influencing risk for dependence. Physiological dependence and associated withdrawal are thought to be a powerful motivational force that perpetuates sedative-hypnotic use/abuse, and enhances vulnerability to relapse. Recently, the substantia nigra pars reticulata (SNr) has been identified as crucially involved in sedative-hypnotic withdrawal symptoms (e.g., convulsions). The Mpdz gene has been implicated in sedative-hypnotic physiological dependence and associated withdrawal episodes in mice, with Mpdz expression within the caudolateral subregion of the SNr crucially involved.

Original languageEnglish (US)
Title of host publicationGeneral Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions
PublisherElsevier Inc.
Number of pages11
ISBN (Electronic)9780128006771
ISBN (Print)9780128006344
StatePublished - May 13 2016


  • Alcohol
  • Barbiturate
  • Benzodiazepine
  • Dependence
  • GABA
  • Genetic
  • MUPP1
  • Mpdz
  • Sedative
  • Substantia nigra
  • Withdrawal

ASJC Scopus subject areas

  • Medicine(all)


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