The Substantia Nigra Pars Reticulata in Sedative-Hypnotic Withdrawal

Lauren C. Kruse; Kari J. Buck

doi:10.1016/B978-0-12-800634-4.00034-2

The Substantia Nigra Pars Reticulata in Sedative-Hypnotic Withdrawal

Lauren C. Kruse, Kari J. Buck

Behavioral Neuroscience

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Sedative-hypnotic drugs including alcohol, benzodiazepines, and barbiturates, are widely used and abused for their euphoric and sedative properties. Sedative-hypnotic abuse and addiction is a complex, heterogeneous disorder, with biological (genetic) factors strongly influencing risk for dependence. Physiological dependence and associated withdrawal are thought to be a powerful motivational force that perpetuates sedative-hypnotic use/abuse, and enhances vulnerability to relapse. Recently, the substantia nigra pars reticulata (SNr) has been identified as crucially involved in sedative-hypnotic withdrawal symptoms (e.g., convulsions). The Mpdz gene has been implicated in sedative-hypnotic physiological dependence and associated withdrawal episodes in mice, with Mpdz expression within the caudolateral subregion of the SNr crucially involved.

Original language	English (US)
Title of host publication	General Processes and Mechanisms, Prescription Medications, Caffeine and Areca, Polydrug Misuse, Emerging Addictions and Non-Drug Addictions
Publisher	Elsevier Inc.
Pages	345-355
Number of pages	11
Volume	3
ISBN (Electronic)	9780128006771
ISBN (Print)	9780128006344
DOIs	https://doi.org/10.1016/B978-0-12-800634-4.00034-2
State	Published - May 13 2016

Keywords

Alcohol
Barbiturate
Benzodiazepine
Dependence
GABA
Genetic
MUPP1
Mpdz
Sedative
Substantia nigra
Withdrawal

ASJC Scopus subject areas

Medicine(all)

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10.1016/B978-0-12-800634-4.00034-2

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abstract = "Sedative-hypnotic drugs including alcohol, benzodiazepines, and barbiturates, are widely used and abused for their euphoric and sedative properties. Sedative-hypnotic abuse and addiction is a complex, heterogeneous disorder, with biological (genetic) factors strongly influencing risk for dependence. Physiological dependence and associated withdrawal are thought to be a powerful motivational force that perpetuates sedative-hypnotic use/abuse, and enhances vulnerability to relapse. Recently, the substantia nigra pars reticulata (SNr) has been identified as crucially involved in sedative-hypnotic withdrawal symptoms (e.g., convulsions). The Mpdz gene has been implicated in sedative-hypnotic physiological dependence and associated withdrawal episodes in mice, with Mpdz expression within the caudolateral subregion of the SNr crucially involved.",

keywords = "Alcohol, Barbiturate, Benzodiazepine, Dependence, GABA, Genetic, MUPP1, Mpdz, Sedative, Substantia nigra, Withdrawal",

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AU - Buck, Kari J.

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N2 - Sedative-hypnotic drugs including alcohol, benzodiazepines, and barbiturates, are widely used and abused for their euphoric and sedative properties. Sedative-hypnotic abuse and addiction is a complex, heterogeneous disorder, with biological (genetic) factors strongly influencing risk for dependence. Physiological dependence and associated withdrawal are thought to be a powerful motivational force that perpetuates sedative-hypnotic use/abuse, and enhances vulnerability to relapse. Recently, the substantia nigra pars reticulata (SNr) has been identified as crucially involved in sedative-hypnotic withdrawal symptoms (e.g., convulsions). The Mpdz gene has been implicated in sedative-hypnotic physiological dependence and associated withdrawal episodes in mice, with Mpdz expression within the caudolateral subregion of the SNr crucially involved.

AB - Sedative-hypnotic drugs including alcohol, benzodiazepines, and barbiturates, are widely used and abused for their euphoric and sedative properties. Sedative-hypnotic abuse and addiction is a complex, heterogeneous disorder, with biological (genetic) factors strongly influencing risk for dependence. Physiological dependence and associated withdrawal are thought to be a powerful motivational force that perpetuates sedative-hypnotic use/abuse, and enhances vulnerability to relapse. Recently, the substantia nigra pars reticulata (SNr) has been identified as crucially involved in sedative-hypnotic withdrawal symptoms (e.g., convulsions). The Mpdz gene has been implicated in sedative-hypnotic physiological dependence and associated withdrawal episodes in mice, with Mpdz expression within the caudolateral subregion of the SNr crucially involved.

KW - Alcohol

KW - Barbiturate

KW - Benzodiazepine

KW - Dependence

KW - GABA

KW - Genetic

KW - MUPP1

KW - Mpdz

KW - Sedative

KW - Substantia nigra

KW - Withdrawal

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PB - Elsevier Inc.

ER -

The Substantia Nigra Pars Reticulata in Sedative-Hypnotic Withdrawal

Abstract

Keywords

ASJC Scopus subject areas

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