The synthesis of 13C9-15N-labeled 3,5-diiodothyronine and thyroxine

Sarah A. Hackenmueller, Thomas S. Scanlan

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Thyroid hormones undergo extensive metabolism to regulate hormone activity. A labeled thyroid hormone would be useful to track hormone metabolism through various pathways. While radiolabeled thyroid hormones have been synthesized and used for in vivo studies, a stable isotope labeled form of thyroid hormone is required for studying thyroid hormone metabolism by LC-MS/MS, an analytical technique that has certain advantages without the complications of radioactivity. Here we report the synthesis of 13C9- 15N-T2 and 13C9-15N- T4, two labeled thyroid hormone derivatives suitable for in vivo LC-MS/MS studies. Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications® to view the free supplemental file.

Original languageEnglish (US)
Pages (from-to)1439-1446
Number of pages8
JournalSynthetic Communications
Issue number10
StatePublished - May 15 2013


  • C -N-T
  • C-N-T
  • Thyroid hormone
  • Thyroxine

ASJC Scopus subject areas

  • Organic Chemistry


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