The transparent lens and cornea in the mouse and zebra fish eye

Teri M.S. Greiling, John I. Clark

Research output: Contribution to journalReview articlepeer-review

34 Scopus citations


The lens and cornea combine to form a single optical element in which transparency and refraction are the fundamental biophysical characteristics required for a functional visual system. Although lens and cornea have different cellular and extracellular specializations that contribute to transparency and refraction, their development is closely related. In the embryonic mouse, the developing cornea and lens separate early. In contrast, zebra fish lens and cornea remain connected during early development and the optical properties of the cornea and lens observed by slit lamp and quasielastic laser light scattering spectroscopy (QLS) are more similar in the zebra fish eye than in the mouse eye. Optical similarities between cornea and lens of zebra fish may be the result of similarities in the cellular development of the cornea and lens.

Original languageEnglish (US)
Pages (from-to)94-99
Number of pages6
JournalSeminars in Cell and Developmental Biology
Issue number2
StatePublished - Apr 2008
Externally publishedYes


  • Cornea
  • Lens
  • Optical development
  • Refracton
  • Transparency
  • Zebra fish

ASJC Scopus subject areas

  • Developmental Biology
  • Cell Biology


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