Therapeutic new era for atopic dermatitis: Part 2. Small molecules

Jiyoung Ahn, Yusung Choi, Eric Lawrence Simpson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Atopic dermatitis (AD) is a chronic, inflammatory cutaneous disease driven by immune dysregulation and skin barrier dysfunction. Currently, we are experiencing a new era of understanding of the pathogenesis of AD and, as a consequence, a new era of innovation in therapeutics, including small molecules and biologic therapy. In contrast to biologics, small molecules are similar to conventional pharmacologic chemical agents used as drugs and are generally prepared by chemical synthesis. Unlike biologics, these drugs often are taken orally or formulated for topical use. The purpose of this review is to summarize the efficacy and safety of the current topical and systemic new therapies in AD by reviewing recently published papers on therapies currently in phase 2 or 3 clinical trials. In this review, it is important to note the characteristics of the study population, the primary endpoints, and whether or not there was concomitant topical therapy allowed. These study design elements may significantly alter the results of studies and should be taken into account. Targeted therapy help push AD treatment into a new era of personalized medicine.

Original languageEnglish (US)
Pages (from-to)101-107
Number of pages7
JournalAnnals of Dermatology
Issue number2
StatePublished - Apr 2021


  • Atopic dermatitis
  • New era
  • Small molecules
  • Therapeutics

ASJC Scopus subject areas

  • Dermatology


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