Therapy of Experimental Herpes Simplex Keratitis in Rabbits with 5-lodo-5′-Amino-2′,5′-Dideoxyuridine

Carmen A. Puliafito; Nancy L. Robinson; Daniel M. Albert; Deborah Pavan-Langston; Tai Shun Lin; David C. Ward; William H. Prusoff

doi:10.3181/00379727-156-39882

Therapy of Experimental Herpes Simplex Keratitis in Rabbits with 5-lodo-5′-Amino-2′,5′-Dideoxyuridine

Carmen A. Puliafito, Nancy L. Robinson, Daniel M. Albert, Deborah Pavan-Langston, Tai Shun Lin, David C. Ward, William H. Prusoff

Research output: Contribution to journal › Article › peer-review

Abstract

AIU (5-iodo-5′-amino-2′,5′-dideoxyuridine, AIdUrd) has been shown to be as effective as IdUrd in the treatment of experimental herpes simplex keratitis in rabbits. AIU's striking lack of cellular or systemic toxicity or teratogenicity and its specific inhibition of viral metabolism are discussed. The authors acknowledge the valuable technical assistance of Mr. Alfred S. Fiore and Mr. Ronald Callahan (Departments of Pharmacy and Nuclear Medicine, Massachusetts General Hospital). Mrs. Brigitte A. Prusoff performed the statistical analysis.

Original language	English (US)
Pages (from-to)	92-96
Number of pages	5
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	156
Issue number	1
DOIs	https://doi.org/10.3181/00379727-156-39882
State	Published - Oct 1977
Externally published	Yes

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Therapy of Experimental Herpes Simplex Keratitis in Rabbits with 5-lodo-5′-Amino-2′,5′-Dideoxyuridine",

abstract = "AIU (5-iodo-5′-amino-2′,5′-dideoxyuridine, AIdUrd) has been shown to be as effective as IdUrd in the treatment of experimental herpes simplex keratitis in rabbits. AIU's striking lack of cellular or systemic toxicity or teratogenicity and its specific inhibition of viral metabolism are discussed. The authors acknowledge the valuable technical assistance of Mr. Alfred S. Fiore and Mr. Ronald Callahan (Departments of Pharmacy and Nuclear Medicine, Massachusetts General Hospital). Mrs. Brigitte A. Prusoff performed the statistical analysis.",

author = "Puliafito, {Carmen A.} and Robinson, {Nancy L.} and Albert, {Daniel M.} and Deborah Pavan-Langston and Lin, {Tai Shun} and Ward, {David C.} and Prusoff, {William H.}",

note = "Funding Information: This work was supported by United States Public Health Service Grants CA-05262 and CA-16038 from the National Institutes of Cancer and by the United States Energy Research and Development Administration Research Contract E(11-1)-2468. 2 ",

year = "1977",

month = oct,

doi = "10.3181/00379727-156-39882",

language = "English (US)",

volume = "156",

pages = "92--96",

journal = "Experimental Biology and Medicine",

issn = "1535-3702",

publisher = "SAGE Publications Ltd",

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T1 - Therapy of Experimental Herpes Simplex Keratitis in Rabbits with 5-lodo-5′-Amino-2′,5′-Dideoxyuridine

AU - Puliafito, Carmen A.

AU - Robinson, Nancy L.

AU - Albert, Daniel M.

AU - Pavan-Langston, Deborah

AU - Lin, Tai Shun

AU - Ward, David C.

AU - Prusoff, William H.

N1 - Funding Information: This work was supported by United States Public Health Service Grants CA-05262 and CA-16038 from the National Institutes of Cancer and by the United States Energy Research and Development Administration Research Contract E(11-1)-2468. 2

PY - 1977/10

Y1 - 1977/10

N2 - AIU (5-iodo-5′-amino-2′,5′-dideoxyuridine, AIdUrd) has been shown to be as effective as IdUrd in the treatment of experimental herpes simplex keratitis in rabbits. AIU's striking lack of cellular or systemic toxicity or teratogenicity and its specific inhibition of viral metabolism are discussed. The authors acknowledge the valuable technical assistance of Mr. Alfred S. Fiore and Mr. Ronald Callahan (Departments of Pharmacy and Nuclear Medicine, Massachusetts General Hospital). Mrs. Brigitte A. Prusoff performed the statistical analysis.

AB - AIU (5-iodo-5′-amino-2′,5′-dideoxyuridine, AIdUrd) has been shown to be as effective as IdUrd in the treatment of experimental herpes simplex keratitis in rabbits. AIU's striking lack of cellular or systemic toxicity or teratogenicity and its specific inhibition of viral metabolism are discussed. The authors acknowledge the valuable technical assistance of Mr. Alfred S. Fiore and Mr. Ronald Callahan (Departments of Pharmacy and Nuclear Medicine, Massachusetts General Hospital). Mrs. Brigitte A. Prusoff performed the statistical analysis.

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Therapy of Experimental Herpes Simplex Keratitis in Rabbits with 5-lodo-5′-Amino-2′,5′-Dideoxyuridine

Abstract

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