AIU (5-iodo-5′-amino-2′,5′-dideoxyuridine, AIdUrd) has been shown to be as effective as IdUrd in the treatment of experimental herpes simplex keratitis in rabbits. AIU's striking lack of cellular or systemic toxicity or teratogenicity and its specific inhibition of viral metabolism are discussed. The authors acknowledge the valuable technical assistance of Mr. Alfred S. Fiore and Mr. Ronald Callahan (Departments of Pharmacy and Nuclear Medicine, Massachusetts General Hospital). Mrs. Brigitte A. Prusoff performed the statistical analysis.
|Original language||English (US)|
|Number of pages||5|
|Journal||Proceedings of the Society for Experimental Biology and Medicine|
|State||Published - Oct 1977|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)