Therapy of Experimental Herpes Simplex Keratitis in Rabbits with 5-lodo-5′-Amino-2′,5′-Dideoxyuridine

Carmen A. Puliafito, Nancy L. Robinson, Daniel M. Albert, Deborah Pavan-Langston, Tai Shun Lin, David C. Ward, William H. Prusoff

Research output: Contribution to journalArticlepeer-review


AIU (5-iodo-5′-amino-2′,5′-dideoxyuridine, AIdUrd) has been shown to be as effective as IdUrd in the treatment of experimental herpes simplex keratitis in rabbits. AIU's striking lack of cellular or systemic toxicity or teratogenicity and its specific inhibition of viral metabolism are discussed. The authors acknowledge the valuable technical assistance of Mr. Alfred S. Fiore and Mr. Ronald Callahan (Departments of Pharmacy and Nuclear Medicine, Massachusetts General Hospital). Mrs. Brigitte A. Prusoff performed the statistical analysis.

Original languageEnglish (US)
Pages (from-to)92-96
Number of pages5
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
StatePublished - Oct 1977
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)


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