TY - JOUR
T1 - Thrombotic microangiopathy with intraglomerular IgM pseudothrombi in Waldenström macroglobulinemia and IgM monoclonal gammopathy
AU - Tan, Serena Yen Shan
AU - Sibley, Richard Kent
AU - Belani, Sharina
AU - Iwasaki, Sumie
AU - Yankulin, Leonid
AU - Jonelis, Tracy
AU - Higgins, John Patrick Twistington
AU - Kambham, Neeraja
AU - Troxell, Megan Leigh
N1 - Publisher Copyright:
© 2018, Italian Society of Nephrology.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - IgM secreting myelomas or lymphomas, including Waldenström macroglobulinemia, are associated with a varied spectrum of renal pathology, including intracapillary hyaline deposits, cryoglobulin, membranoproliferative glomerulonephritis, amyloid, monoclonal immunoglobulin deposition disease, cast nephropathy, and lymphoma infiltration. We report our single institution experience, and describe five cases with distinctive glomerular pathology: intracapillary IgM pseudothrombi and thrombotic microangiopathic change, with glomerular intracellular crystals in two biopsies. Two patients were hypocomplementemic at presentation. This series adds to the recent literature on paraprotein associated thrombotic microangiopathy.
AB - IgM secreting myelomas or lymphomas, including Waldenström macroglobulinemia, are associated with a varied spectrum of renal pathology, including intracapillary hyaline deposits, cryoglobulin, membranoproliferative glomerulonephritis, amyloid, monoclonal immunoglobulin deposition disease, cast nephropathy, and lymphoma infiltration. We report our single institution experience, and describe five cases with distinctive glomerular pathology: intracapillary IgM pseudothrombi and thrombotic microangiopathic change, with glomerular intracellular crystals in two biopsies. Two patients were hypocomplementemic at presentation. This series adds to the recent literature on paraprotein associated thrombotic microangiopathy.
KW - Hypocomplementemia
KW - IgM paraprotein
KW - Thrombotic microangiopathy
KW - Waldenström macroglobulinemia
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U2 - 10.1007/s40620-018-0544-9
DO - 10.1007/s40620-018-0544-9
M3 - Article
C2 - 30334170
AN - SCOPUS:85055481861
SN - 1121-8428
VL - 31
SP - 907
EP - 918
JO - Journal of Nephrology
JF - Journal of Nephrology
IS - 6
ER -