TY - JOUR
T1 - Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex
AU - Hamann, Martine
AU - Rossi, David J.
AU - Attwell, David
N1 - Funding Information:
This work was supported by the Wellcome Trust, a Burroughs-Wellcome fellowship to D.J.R., and a Royal Society-Wolfson Research Merit Award to D.A. We thank Drs. Wohlfarth, Bianchi, and Macdonald for a preprint of their 2002 paper; Brian Billups for software; Jeremy Lambert for helpful discussion; and Céline Auger, Daniela Billups, Alasdair Gibb, Mike Häusser, Paı̈kan Marcaggi, and Angus Silver for comments on the manuscript.
PY - 2002/2/14
Y1 - 2002/2/14
N2 - We show that information flow through the adult cerebellar cortex, from the mossy fiber input to the Purkinje cell output, is controlled by furosemide-sensitive, diazepam- and neurosteroid-insensitive GABAA receptors on granule cells, which are activated both tonically and by GABA spillover from synaptic release sites. Tonic activation of these receptors contributes a 3-fold larger mean inhibitory conductance than GABA released synaptically by high-frequency stimulation. Tonic and spillover inhibition reduce the fraction of granule cells activated by mossy fiber input, generating an increase of coding sparseness, which is predicted to improve the information storage capacity of the cerebellum.
AB - We show that information flow through the adult cerebellar cortex, from the mossy fiber input to the Purkinje cell output, is controlled by furosemide-sensitive, diazepam- and neurosteroid-insensitive GABAA receptors on granule cells, which are activated both tonically and by GABA spillover from synaptic release sites. Tonic activation of these receptors contributes a 3-fold larger mean inhibitory conductance than GABA released synaptically by high-frequency stimulation. Tonic and spillover inhibition reduce the fraction of granule cells activated by mossy fiber input, generating an increase of coding sparseness, which is predicted to improve the information storage capacity of the cerebellum.
UR - http://www.scopus.com/inward/record.url?scp=0037075234&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037075234&partnerID=8YFLogxK
U2 - 10.1016/S0896-6273(02)00593-7
DO - 10.1016/S0896-6273(02)00593-7
M3 - Article
C2 - 11856535
AN - SCOPUS:0037075234
SN - 0896-6273
VL - 33
SP - 625
EP - 633
JO - Neuron
JF - Neuron
IS - 4
ER -