Topology of signal recognition particle receptor in endoplasmic reticulum membrane

Leander Lauffer; Pablo D. Garcia; Richard N. Harkins; Lisa Coussens; Axel Ullrich; Peter Walter

doi:10.1038/318334a0

Topology of signal recognition particle receptor in endoplasmic reticulum membrane

Leander Lauffer, Pablo D. Garcia, Richard N. Harkins, Lisa Coussens, Axel Ullrich, Peter Walter

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95 Scopus citations

Abstract

The signal recognition particle (SRP) receptor is an integral membrane protein of the endoplasmic reticulum which, in conjunction with SRP, ensures the correct targeting of nascent secretory proteins to this membrane system. From the complementary DNA sequence we have deduced the complete primary structure of the SRP receptor and established that its amino-terminal region is anchored in the membrane. The anchor fragment and the cytoplasmic fragment contribute jointly to a functionally important region which is highly charged and may function in nucleic acid binding.

Original language	English (US)
Pages (from-to)	334-338
Number of pages	5
Journal	Nature
Volume	318
Issue number	6044
DOIs	https://doi.org/10.1038/318334a0
State	Published - 1985
Externally published	Yes

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title = "Topology of signal recognition particle receptor in endoplasmic reticulum membrane",

abstract = "The signal recognition particle (SRP) receptor is an integral membrane protein of the endoplasmic reticulum which, in conjunction with SRP, ensures the correct targeting of nascent secretory proteins to this membrane system. From the complementary DNA sequence we have deduced the complete primary structure of the SRP receptor and established that its amino-terminal region is anchored in the membrane. The anchor fragment and the cytoplasmic fragment contribute jointly to a functionally important region which is highly charged and may function in nucleic acid binding.",

author = "Leander Lauffer and Garcia, {Pablo D.} and Harkins, {Richard N.} and Lisa Coussens and Axel Ullrich and Peter Walter",

year = "1985",

doi = "10.1038/318334a0",

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T1 - Topology of signal recognition particle receptor in endoplasmic reticulum membrane

AU - Lauffer, Leander

AU - Garcia, Pablo D.

AU - Harkins, Richard N.

AU - Coussens, Lisa

AU - Ullrich, Axel

AU - Walter, Peter

PY - 1985

Y1 - 1985

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AB - The signal recognition particle (SRP) receptor is an integral membrane protein of the endoplasmic reticulum which, in conjunction with SRP, ensures the correct targeting of nascent secretory proteins to this membrane system. From the complementary DNA sequence we have deduced the complete primary structure of the SRP receptor and established that its amino-terminal region is anchored in the membrane. The anchor fragment and the cytoplasmic fragment contribute jointly to a functionally important region which is highly charged and may function in nucleic acid binding.

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Topology of signal recognition particle receptor in endoplasmic reticulum membrane

Abstract

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