Abstract
Objectives - To evaluate the feasibility and safety of head-neck cooling in conscious normal volunteers (10) and patients with medically refractory epilepsy (5) without causing shivering. Patients and methods - We used a non-invasive head-neck cooling system (CoolSystems Inc., Lincoln, CA, USA). The tympanic temperature (TT) and intestinal temperature (IT) were measured as two measurements of 'core temperature' (CT), and multi-site external temperatures, several physiologic variables and EEG were monitored. Seizure counts over 4-week precooling, treatment and follow-up phases were compared. Results - All 15 participants completed all the cooling sessions without significant complaints. At the end of 60 min of cooling, scalp temperature fell on average by 12.2°C (P < 0.001), TT by 1.67°C (P < 0.001), and IT by 0.12°C (P = NS). Average weekly seizure frequency decreased from 2.7 to 1.7 events per patient per week (MANOVA: P < 0.05). Conclusions - Non-invasive head-neck cooling is safe and well-tolerated. Initial pilot data in patients suggest that additional therapeutic studies are warranted.
Original language | English (US) |
---|---|
Pages (from-to) | 240-244 |
Number of pages | 5 |
Journal | Acta Neurologica Scandinavica |
Volume | 118 |
Issue number | 4 |
DOIs | |
State | Published - Oct 2008 |
Externally published | Yes |
Keywords
- Brain
- Core temperature
- Cortical excitability
- Epilepsy
- Interictal cooling
- Non-invasive hypothermia
- Seizures
- Treatment
ASJC Scopus subject areas
- Neurology
- Clinical Neurology