TPMT and MTHFR genotype is not associated with altered risk of thioguanine-related sinusoidal obstruction syndrome in pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group

Lisa Wray; Marijana Vujkovic; Thomas Mcwilliams; Shannon Cannon; Meenakshi Devidas; Linda Stork; Richard Aplenc

doi:10.1002/pbc.25057

TPMT and MTHFR genotype is not associated with altered risk of thioguanine-related sinusoidal obstruction syndrome in pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group

Lisa Wray, Marijana Vujkovic, Thomas Mcwilliams, Shannon Cannon, Meenakshi Devidas, Linda Stork, Richard Aplenc

Pediatric Hematology and Oncology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Sinusoidal obstruction syndrome is a complication of therapy for pediatric ALL and may be modified by thiopurine methyltransferase activity as well as by MTHFR genotype. We assessed TPMT *3A, *3B, *3C, and MTHFR C677T and A1298C germline genetic polymorphisms among 351 patients enrolled in the thioguanine treatment arm of CCG-1952 clinical trial. TPMT and MTHFR C677T genotypes were not associated with SOS risk. The combination of MTHFR and TPMT variant genotypes was not associated with SOS risk. These suggest that germline genetic variation in TPMT and MTHFR do not significantly alter SOS risk in patients exposed to thioguanine.

Original language	English (US)
Pages (from-to)	2086-2088
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	61
Issue number	11
DOIs	https://doi.org/10.1002/pbc.25057
State	Published - Nov 1 2014

Keywords

Acute lymphoblastic leukemia
MTHFR
SOS
TPMT
Thioguanine
Toxicity

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.25057

Cite this

Wray, L., Vujkovic, M., Mcwilliams, T., Cannon, S., Devidas, M., Stork, L., & Aplenc, R. (2014). TPMT and MTHFR genotype is not associated with altered risk of thioguanine-related sinusoidal obstruction syndrome in pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group. Pediatric Blood and Cancer, 61(11), 2086-2088. https://doi.org/10.1002/pbc.25057

TPMT and MTHFR genotype is not associated with altered risk of thioguanine-related sinusoidal obstruction syndrome in pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group. / Wray, Lisa; Vujkovic, Marijana; Mcwilliams, Thomas et al.
In: Pediatric Blood and Cancer, Vol. 61, No. 11, 01.11.2014, p. 2086-2088.

Research output: Contribution to journal › Article › peer-review

Wray, L, Vujkovic, M, Mcwilliams, T, Cannon, S, Devidas, M, Stork, L & Aplenc, R 2014, 'TPMT and MTHFR genotype is not associated with altered risk of thioguanine-related sinusoidal obstruction syndrome in pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group', Pediatric Blood and Cancer, vol. 61, no. 11, pp. 2086-2088. https://doi.org/10.1002/pbc.25057

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title = "TPMT and MTHFR genotype is not associated with altered risk of thioguanine-related sinusoidal obstruction syndrome in pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group",

abstract = "Sinusoidal obstruction syndrome is a complication of therapy for pediatric ALL and may be modified by thiopurine methyltransferase activity as well as by MTHFR genotype. We assessed TPMT *3A, *3B, *3C, and MTHFR C677T and A1298C germline genetic polymorphisms among 351 patients enrolled in the thioguanine treatment arm of CCG-1952 clinical trial. TPMT and MTHFR C677T genotypes were not associated with SOS risk. The combination of MTHFR and TPMT variant genotypes was not associated with SOS risk. These suggest that germline genetic variation in TPMT and MTHFR do not significantly alter SOS risk in patients exposed to thioguanine.",

keywords = "Acute lymphoblastic leukemia, MTHFR, SOS, TPMT, Thioguanine, Toxicity",

author = "Lisa Wray and Marijana Vujkovic and Thomas Mcwilliams and Shannon Cannon and Meenakshi Devidas and Linda Stork and Richard Aplenc",

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TPMT and MTHFR genotype is not associated with altered risk of thioguanine-related sinusoidal obstruction syndrome in pediatric acute lymphoblastic leukemia: A report from the Children's Oncology Group

Abstract

Keywords

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