Abstract
Messmer et al. demonstrate that the single-cell transcriptomes of naive and primed human embryonic stem cells (hESCs) are mostly homogeneous. The study defines an expression signature that is conserved across species and shows differential epigenetic regulation between naive and primed pluripotency.
Original language | English (US) |
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Pages (from-to) | 815-824.e4 |
Journal | Cell Reports |
Volume | 26 |
Issue number | 4 |
DOIs | |
State | Published - Jan 22 2019 |
Externally published | Yes |
Keywords
- early embryonic development
- evolution
- heterogeneity
- human embryonic stem cells
- naive
- pluripotency
- primed
- single-cell RNA-seq
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology