Transgenic mice expressing mutated full-length HD cDNA: A paradigm for locomotor changes and selective neuronal loss in Huntington's disease

Medicine & Life Sciences

• Huntington Disease 100%
• Transgenic Mice 80%
• Transgenes 77%
• Complementary DNA 72%
• polyglutamine 50%
• Gliosis 45%
• Cerebral Cortex 35%
• Brain 25%
• Hippocampus 20%
• Animals 19%
• Hyperkinesis 18%
• Trinucleotide Repeats 17%
• Intranuclear Inclusion Bodies 17%
• Grooming 16%
• Staining and Labeling 16%
• Genetically Modified Animals 16%
• Wild Animals 15%
• Neurons 15%
• Forelimb 15%
• Gonads 14%
• Hindlimb 14%
• Southern Blotting 14%
• In Situ Nick-End Labeling 13%
• Cytomegalovirus 12%
• Thalamus 12%
• Tail 12%
• Cerebellum 11%
• Neurodegenerative Diseases 11%
• Exons 10%
• Spleen 10%
• Cell Death 9%
• Psychiatry 9%
• Urine 9%
• Western Blotting 8%
• Heart 8%
• Mutation 7%
• Kidney 6%
• Lung 6%
• Liver 6%

Agriculture & Biology

• genetically modified organisms 68%
• transgenes 65%
• mice 51%
• cerebral cortex 40%
• brain 31%
• hippocampus 25%
• neurons 18%
• staining 16%
• Cytomegalovirus 15%
• disease models 15%
• transgenic animals 14%
• neurodegenerative diseases 14%
• thalamus 14%
• animals 14%
• forelimbs 13%
• hindlimbs 13%
• cerebellum 12%
• cell death 10%
• Southern blotting 10%
• pathogenesis 10%
• exons 10%
• gonads 10%
• animal models 9%
• Western blotting 9%
• spleen 9%
• tail 9%
• lungs 8%
• heart 8%
• death 8%
• promoter regions 8%
• kidneys 8%
• mutation 7%
• liver 6%

Chemical Compounds

• Complementary DNA 93%
• Disorder 77%
• Apoptotic 51%
• Cell Death 48%
• Mutation 38%
• Time 16%