TY - JOUR
T1 - Transposition of a plasmid deoxyribonucleic acid sequence that mediates ampicillin resistance
T2 - identity of laboratory constructed plasmids and clinical isolates
AU - Heffron, F.
AU - Rubens, C.
AU - Falkow, S.
N1 - Copyright:
Copyright 2004 Elsevier B.V., All rights reserved.
PY - 1977
Y1 - 1977
N2 - The structural gene for ampicillin resistance residues upon a 3.2 x 106 dalton sequence of deoxyribonucleic acid, TnA, that can be transposed from replicon to replicon in laboratory experiments. TnA was transposed from a large conjugative plasmid to a small nonconjugative plasmid, RSF1010. Several RSF1010::TnA plasmids isolated in these laboratory experiments have been shown to be identical to plasmids found in clinical isolates. These data provide direct support to the theory that transposition of drug resistance genes play a key role in the evolution of R plasmids.
AB - The structural gene for ampicillin resistance residues upon a 3.2 x 106 dalton sequence of deoxyribonucleic acid, TnA, that can be transposed from replicon to replicon in laboratory experiments. TnA was transposed from a large conjugative plasmid to a small nonconjugative plasmid, RSF1010. Several RSF1010::TnA plasmids isolated in these laboratory experiments have been shown to be identical to plasmids found in clinical isolates. These data provide direct support to the theory that transposition of drug resistance genes play a key role in the evolution of R plasmids.
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M3 - Article
C2 - 583751
AN - SCOPUS:0017335516
SN - 0021-9193
VL - 129
SP - 530
EP - 533
JO - Journal of bacteriology
JF - Journal of bacteriology
IS - 1
ER -