Treatment of metastatic uveal melanoma: Review and recommendations

Daniel M. Albert, Arysol Soltero Niffenegger, James K.V. Willson

Research output: Contribution to journalReview articlepeer-review

112 Scopus citations


This article reviews the published clinical responses of metastatic uveal melanoma and metastatic cutaneous melanoma with visceral involvement to current therapeutic protocols. Despite isolated patient responses to systemic treatment, no effective treatment currently exists for metastatic uveal melanoma. However, several new approaches involving interferons and interleukin and combination chemotherapy have shown some activity against metastatic cutaneous melanoma. The effectiveness against metastatic uveal melanomas has not been determined. A new approach to intrahepatic administration of chemotherapy also warrants further evaluation because of the high incidence of hepatic involvement with metastatic uveal melanoma. When an effective systemic treatment is found, early administration as an adjuvant to primary treatment may provide the best strategy for control of systemic spread.

Original languageEnglish (US)
Pages (from-to)429-438
Number of pages10
JournalSurvey of Ophthalmology
Issue number6
StatePublished - 1992
Externally publishedYes


  • chemotherapy
  • cutaneous melanoma
  • immunotherapy
  • malignant melanoma
  • uveal melanoma

ASJC Scopus subject areas

  • Ophthalmology


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