Treatment of neuroblastoma in patients with neurocristopathy syndromes

Eneida R. Nemecek, Robert W. Sawin, Julie Park

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Neuroblastoma, a neoplasm of neural crest cell origin, occasionally presents in association with other neural crest abnormalities such as Hirschsprung disease, congenital central hypoventilation, autonomic disturbances, and other tumors. These associations have been termed "neurocristopathy syndromes." In the past, chemotherapy has not been considered for patients with neurocristopathy-associated neuroblastoma because of their complicated medical problems. The authors describe two patients with neurocristopathy syndromes from our institution who underwent surgery and standard chemotherapy treatment of their intermediate-risk neuroblastoma. They represent two of only three long-term disease-free survivors of neurocristopathy-associated neuroblastoma reported in the literature.

Original languageEnglish (US)
Pages (from-to)159-162
Number of pages4
JournalJournal of Pediatric Hematology/Oncology
Issue number2
StatePublished - Feb 2003
Externally publishedYes


  • Congenital central hypoventilation syndrome
  • Hirschsprung disease
  • Neuroblastoma
  • Neurocristopathy

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology


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