Treatment options for recurrent high-grade gliomas

Harjus S. Birk, Seunggu J. Han, Nicholas A. Butowski

Research output: Contribution to journalReview articlepeer-review

45 Scopus citations


High-grade gliomas are aggressive brain tumors encompassing Grade III and IV classifications. Of these, glioblastoma (GB) is the most malignant with a high rate of recurrence after initial resection. Although standard treatment does exist for newly diagnosed GBs, therapeutic strategies for recurrent GB are less solidified. However, mounting evidence describes the role of re-resection, bevacizumab, chemotherapy, targeted molecular therapies, immunotherapeutic approaches and radiotherapy in recurrent GB management. This review article provides analysis of the aforementioned therapies, through assessing their effect on overall survival. Because GB tumor heterogeneity is prevalent there is a constant need to investigate therapies targeting recurrence. Studies evaluating both therapeutic targets and strategies for high-grade gliomas are and will remain invaluable.

Original languageEnglish (US)
Pages (from-to)61-70
Number of pages10
JournalCNS oncology
Issue number1
StatePublished - Jan 1 2017


  • glioblastoma
  • high-grade gliomas
  • overall survival
  • progression-free survival
  • recurrence treatment

ASJC Scopus subject areas

  • Medicine(all)


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