TY - JOUR
T1 - Trichodysplasia spinulosa mimicking lichen nitidus in a renal transplant patient
AU - Barone, Hope
AU - Brockman, Ross
AU - Johnson, Luke
AU - Al-Uzri, Amira
AU - Wright, Mary
AU - Mengden-Koon, Stephanie
AU - Funk, Tracy
N1 - Publisher Copyright:
© 2019 Wiley Periodicals, Inc.
PY - 2019/6
Y1 - 2019/6
N2 - Trichodysplasia spinulosa (TS) is a rare cutaneous condition associated with the TSPyV and characterized by skin-colored, folliculocentric papules with keratin spicule formation. TS is seen almost exclusively in immunosuppressed individuals, often presenting in patients with a history of solid organ transplantation or chemotherapy for a lymphoreticular malignancy. We report a case of widespread TS in a 9-year-old girl with a history of renal transplantation complicated by BK viremia, which is also caused by a polyomavirus, BKPyV. The clinical presentation of TS in this case morphologically resembled the more common, harmless skin condition known as “lichen nitidus,” and was more extensive than expected for TS, creating a diagnostic challenge. This case illustrates an important presentation of severe TS of which transplant teams, oncologists, primary care providers, and dermatologists should be aware.
AB - Trichodysplasia spinulosa (TS) is a rare cutaneous condition associated with the TSPyV and characterized by skin-colored, folliculocentric papules with keratin spicule formation. TS is seen almost exclusively in immunosuppressed individuals, often presenting in patients with a history of solid organ transplantation or chemotherapy for a lymphoreticular malignancy. We report a case of widespread TS in a 9-year-old girl with a history of renal transplantation complicated by BK viremia, which is also caused by a polyomavirus, BKPyV. The clinical presentation of TS in this case morphologically resembled the more common, harmless skin condition known as “lichen nitidus,” and was more extensive than expected for TS, creating a diagnostic challenge. This case illustrates an important presentation of severe TS of which transplant teams, oncologists, primary care providers, and dermatologists should be aware.
KW - antibody-mediated rejection
KW - donor-specific antibodies
KW - intravenous gamma globulin
KW - polymerase chain reaction
KW - trichodysplasia spinulosa
KW - trichodysplasia spinulosa-associated polyomavirus
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U2 - 10.1111/petr.13394
DO - 10.1111/petr.13394
M3 - Article
C2 - 30916861
AN - SCOPUS:85063590300
SN - 1397-3142
VL - 23
JO - Pediatric transplantation
JF - Pediatric transplantation
IS - 4
M1 - e13394
ER -