Trisomy 12 is a consistent chromosomal aberration in benign ovarian tumors

Tanja Pejovic, Sverre Heim, Nils Mandahl, Bengt Elmfors, Ulla‐Maria ‐M Flodérus, Stefan Furgyik, Góran Helm, Helena Willén, Felix Mitelman

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50 Scopus citations


Clonal karyotypic abnormalities were detected in 7 of 42 cytogenetically analyzed benign ovarian tumors. An adenofibroma had –X and a mucinous cystadenoma had t(1;11)(q25;q23) as the sole abnormality. Trisomy 12 was found in the remaining five tumors. It was the only change in two fibromas and a serous cystadenoma; the fourth tumor, a mucinous cystadenoma, had one clone with + 12 and one with + 12 and + 10, and the fifth tumor, a fibrothecoma, had +4, +9, +12. The finding of trisomy 12 in five of seven karyotypically aberrant tumors suggests that this aberration characterizes a hitherto unrecognized cytogenetic subgroup of benign ovarian neoplasms.

Original languageEnglish (US)
Pages (from-to)48-52
Number of pages5
JournalGenes, Chromosomes and Cancer
Issue number1
StatePublished - May 1990
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Cancer Research


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