Two Cases of Chronic Central Serous Chorioretinopathy Successfully Treated with Systemic Interferon Alpha

Lingling Huang; Christina Flaxel; Eric Suhler; Phoebe Lin

doi:10.1080/09273948.2023.2226206

Two Cases of Chronic Central Serous Chorioretinopathy Successfully Treated with Systemic Interferon Alpha

Lingling Huang, Christina Flaxel, Eric Suhler, Phoebe Lin

Ophthalmology

Research output: Contribution to journal › Letter › peer-review

Abstract

Chronic central serous chorioretinopathy (CSCR) is a sight threatening disease that can lead to legal blindness. Verteporfin photodynamic therapy is the main treatment for chronic CSCR, however, there has been a critical worldwide shortage of verteporfin. Other medical treatments have been attempted with variable efficacy. Interferons have shown efficacy in treating uveitis and associated macular edema. We report 2 cases of treatment refractory chronic CSCR successfully treated with subcutaneous injection of interferon alpha with significant anatomical and functional improvement. To our knowledge, this is the first report observing the therapeutic potential of systemic interferon alpha in the treatment of chronic CSCR. A large randomized controlled clinical trial would help to better evaluate the safety and efficacy of systemic PEG-IFNα2a in treating chronic CSCR, and further define the optimal dose, treatment interval and duration.

Original language	English (US)
Journal	Ocular Immunology and Inflammation
DOIs	https://doi.org/10.1080/09273948.2023.2226206
State	Accepted/In press - 2023

Keywords

Chronic central serous chorioretinopathy (CSCR)
diagnosis and treatment
interferon alpha treatment
retina
uveitis

ASJC Scopus subject areas

Immunology and Allergy
Ophthalmology

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10.1080/09273948.2023.2226206

Cite this

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title = "Two Cases of Chronic Central Serous Chorioretinopathy Successfully Treated with Systemic Interferon Alpha",

abstract = "Chronic central serous chorioretinopathy (CSCR) is a sight threatening disease that can lead to legal blindness. Verteporfin photodynamic therapy is the main treatment for chronic CSCR, however, there has been a critical worldwide shortage of verteporfin. Other medical treatments have been attempted with variable efficacy. Interferons have shown efficacy in treating uveitis and associated macular edema. We report 2 cases of treatment refractory chronic CSCR successfully treated with subcutaneous injection of interferon alpha with significant anatomical and functional improvement. To our knowledge, this is the first report observing the therapeutic potential of systemic interferon alpha in the treatment of chronic CSCR. A large randomized controlled clinical trial would help to better evaluate the safety and efficacy of systemic PEG-IFNα2a in treating chronic CSCR, and further define the optimal dose, treatment interval and duration.",

keywords = "Chronic central serous chorioretinopathy (CSCR), diagnosis and treatment, interferon alpha treatment, retina, uveitis",

author = "Lingling Huang and Christina Flaxel and Eric Suhler and Phoebe Lin",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.",

year = "2023",

doi = "10.1080/09273948.2023.2226206",

language = "English (US)",

journal = "Ocular Immunology and Inflammation",

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T1 - Two Cases of Chronic Central Serous Chorioretinopathy Successfully Treated with Systemic Interferon Alpha

AU - Huang, Lingling

AU - Flaxel, Christina

AU - Suhler, Eric

AU - Lin, Phoebe

PY - 2023

Y1 - 2023

N2 - Chronic central serous chorioretinopathy (CSCR) is a sight threatening disease that can lead to legal blindness. Verteporfin photodynamic therapy is the main treatment for chronic CSCR, however, there has been a critical worldwide shortage of verteporfin. Other medical treatments have been attempted with variable efficacy. Interferons have shown efficacy in treating uveitis and associated macular edema. We report 2 cases of treatment refractory chronic CSCR successfully treated with subcutaneous injection of interferon alpha with significant anatomical and functional improvement. To our knowledge, this is the first report observing the therapeutic potential of systemic interferon alpha in the treatment of chronic CSCR. A large randomized controlled clinical trial would help to better evaluate the safety and efficacy of systemic PEG-IFNα2a in treating chronic CSCR, and further define the optimal dose, treatment interval and duration.

AB - Chronic central serous chorioretinopathy (CSCR) is a sight threatening disease that can lead to legal blindness. Verteporfin photodynamic therapy is the main treatment for chronic CSCR, however, there has been a critical worldwide shortage of verteporfin. Other medical treatments have been attempted with variable efficacy. Interferons have shown efficacy in treating uveitis and associated macular edema. We report 2 cases of treatment refractory chronic CSCR successfully treated with subcutaneous injection of interferon alpha with significant anatomical and functional improvement. To our knowledge, this is the first report observing the therapeutic potential of systemic interferon alpha in the treatment of chronic CSCR. A large randomized controlled clinical trial would help to better evaluate the safety and efficacy of systemic PEG-IFNα2a in treating chronic CSCR, and further define the optimal dose, treatment interval and duration.

KW - Chronic central serous chorioretinopathy (CSCR)

KW - diagnosis and treatment

KW - interferon alpha treatment

KW - retina

KW - uveitis

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Two Cases of Chronic Central Serous Chorioretinopathy Successfully Treated with Systemic Interferon Alpha

Abstract

Keywords

ASJC Scopus subject areas

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