Two insulin genes are present in the salmon genome

Vadim Kavsan, Anatoliy Koval, Olexiy Petrenko, Charles T. Roberts, Derek Leroith

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


According to the accepted hypothesis, polyploid evolution is necessary to achieve meaningful gene duplication. Some fish, namely those belonging to the suborder Salmonidae, appear to be autotetraploid species that probably originated from a diploid ancestor relatively recently and that appear to be progressing toward diploidization to various degrees. The Pacific chum salmon (Oncorhynchus keta) has almost completed this process of diploidization. Thus, with regard to practically any gene product, theory predicts a freshly diploidized, autotetraploid species to possess twice the number of gene loci as diploid animals. Here we show that the chum salmon genome contains two nonallelic insulin genes that are both expressed in chum salmon Brockman bodies. Nucleotide sequence analysis reveals structural diversification of this pair of duplicated genes.

Original languageEnglish (US)
Pages (from-to)1373-1378
Number of pages6
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - Mar 31 1993
Externally publishedYes

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


Dive into the research topics of 'Two insulin genes are present in the salmon genome'. Together they form a unique fingerprint.

Cite this