Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump

Xuan Qin; Brian Poon; Justin Kwong; Denver Niles; Byron Z. Schmidt; Lakshmi Rajagopal; Soren Gantt

doi:10.1016/j.ijantimicag.2011.03.007

Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump

Xuan Qin, Brian Poon, Justin Kwong, Denver Niles, Byron Z. Schmidt, Lakshmi Rajagopal, Soren Gantt

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Two clinical Staphylococcus aureus isolates were investigated due to their unusual antimicrobial susceptibility pattern, i.e. erythromycin-susceptible but clindamycin-resistant. These isolates harboured identical copies of a plasmid-borne vga(A)_LC gene not previously described in S. aureus. The native plasmids carrying vga(A)_LC were transferable to a susceptible laboratory strain of S. aureus in vitro, in which they conferred resistance patterns similar to the parent isolates.

Original language	English (US)
Pages (from-to)	81-83
Number of pages	3
Journal	International Journal of Antimicrobial Agents
Volume	38
Issue number	1
DOIs	https://doi.org/10.1016/j.ijantimicag.2011.03.007
State	Published - Jul 2011
Externally published	Yes

Keywords

Clindamycin
Efflux pump
Staphylococcus aureus

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases
Pharmacology (medical)

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10.1016/j.ijantimicag.2011.03.007

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Qin, X., Poon, B., Kwong, J., Niles, D., Schmidt, B. Z., Rajagopal, L., & Gantt, S. (2011). Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump. International Journal of Antimicrobial Agents, 38(1), 81-83. https://doi.org/10.1016/j.ijantimicag.2011.03.007

Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump. / Qin, Xuan; Poon, Brian; Kwong, Justin et al.
In: International Journal of Antimicrobial Agents, Vol. 38, No. 1, 07.2011, p. 81-83.

Research output: Contribution to journal › Article › peer-review

Qin, X, Poon, B, Kwong, J, Niles, D, Schmidt, BZ, Rajagopal, L & Gantt, S 2011, 'Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump', International Journal of Antimicrobial Agents, vol. 38, no. 1, pp. 81-83. https://doi.org/10.1016/j.ijantimicag.2011.03.007

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Two paediatric cases of skin and soft-tissue infections due to clindamycin-resistant Staphylococcus aureus carrying a plasmid-encoded vga(A) allelic variant for a putative efflux pump

Abstract

Keywords

ASJC Scopus subject areas

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